[3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenoxy]tert-butylacetate

Base Information

Chemical Name:[3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenoxy]tert-butylacetate
CAS No.:328236-48-2
Molecular Formula:C₂₆H₃₆O₅
Molecular Weight:428.569
Hs Code.:

Synonyms:[3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenoxy]tert-butylacetate

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Chemical Property of [3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenoxy]tert-butylacetate

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Technology Process of [3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenoxy]tert-butylacetate

There total 8 articles about [3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenoxy]tert-butylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 107-59-5
tert-Butyl chloroacetate

: 328236-47-1
3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenol

: 328236-48-2
[3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenoxy]tert-butylacetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;
DOI:10.1016/S0960-894X(00)00531-X

Reference yield:

: 7463-51-6
4-bromo-3,5-dimethylphenol

: 328236-48-2
[3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenoxy]tert-butylacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 81 percent / imidazole / CH₂Cl₂ / 1 h

2.1: n-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C

2.2: 70 percent / tetrahydrofuran; pentane / 2.5 h / -78 - 20 °C

3.1: n-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C

3.2: 68 percent / tetrahydrofuran; pentane / 7 h / -78 - 20 °C

4.1: 80 percent / AcOH; H₂ / 10 percent Pd/C / ethanol / 12 h / 20 °C / 760 Torr

5.1: 90 percent / TBAF / tetrahydrofuran

6.1: 90 percent / Cs₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; pentane;
DOI:10.1016/S0960-894X(00)00531-X

Reference yield:

: 26307-50-6
4-bromo-2-isopropyl-phenol

: 328236-48-2
[3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenoxy]tert-butylacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 20 °C

1.2: 90 percent / dimethylformamide / 0.5 h

2.1: n-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C

2.2: 68 percent / tetrahydrofuran; pentane / 7 h / -78 - 20 °C

3.1: 80 percent / AcOH; H₂ / 10 percent Pd/C / ethanol / 12 h / 20 °C / 760 Torr

4.1: 90 percent / TBAF / tetrahydrofuran

5.1: 90 percent / Cs₂CO₃ / dimethylformamide / 0.5 h / 20 °C

With n-butyllithium; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; caesium carbonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; pentane;
DOI:10.1016/S0960-894X(00)00531-X