methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate

Base Information

Chemical Name:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate
CAS No.:1445790-77-1
Molecular Formula:C₂₉H₂₈FN₅O₅
Molecular Weight:545.57
Hs Code.:

Synonyms:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate

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Chemical Property of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate

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Technology Process of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate

There total 11 articles about methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1445790-75-9
methyl 3-((7-bromo-3-carbamoyl-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445790-77-1
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 120 ℃; for 1.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 58534-95-5
3-bromo-2-fluorobenzenamine

: 1445790-77-1
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1 h / 100 °C

2.1: diphenylether / 16 h / 240 °C

3.1: potassium hydroxide; water / tetrahydrofuran; methanol / 20 h / 45 °C

4.1: trichlorophosphate / 3 h / 110 °C

4.2: Cooling with ice

5.1: acetic acid / 2 h / 20 °C

6.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; caesium carbonate; acetic acid; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diphenylether; water;

Reference yield:

: 1445790-46-4
methyl 3-amino-5-cyclopentylbenzoate

: 1445790-77-1
methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-fluoroquinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 2 h / 20 °C

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 1.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; acetic acid; In 1,4-dioxane; water;