58534-95-5

Basic information

• Product Name: 3-Bromo-2-fluoroaniline
• Synonyms: 3-Bromo-2-fluoroaniline;3-bromo-2-fluoroaniline hydrochloride;3-Bromo-2-fluoroaniline 99%;3-Bromo-2-fluorophenylamine;BenzenaMine, 3-broMo-2-fluoro-;3-Brome-2-fluoroaniline
• CAS NO: 58534-95-5
• Molecular Formula: C₆H₅BrFN
• Molecular Weight: 190.0130032
• Mol File: 58534-95-5.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 228℃
• Flash Point: 91℃
• Appearance: /
• Density: 1.694
• Vapor Pressure: 0.077mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.13±0.10(Predicted)
• CAS DataBase Reference: 3-Bromo-2-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-2-fluoroaniline(58534-95-5)
• EPA Substance Registry System: 3-Bromo-2-fluoroaniline(58534-95-5)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 58534-95-5(Hazardous Substances Data)

Usage

Uses

3-Bromo-2-fluoroaniline is used in the preparation of heterotricyclic carboxamides as RIG-1 agonists for treatment cell proliferation disorders.

InChI:InChI=1/C6H5BrFN/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2

Upstream product

• 848440-23-3 (3-bromo-2-fluorophenyl)carbamic acid tert-butyl ester 
• 161957-56-8 3-bromo-2-fluorobenzoic acid 
• 58534-94-4 2-fluoro-3-bromonitrobenzene 

Downstream Products

• 1184298-53-0 N-(3-bromo-2-fluoro-phenyl)-4-chloro-butyramide 
• 1231892-80-0 2-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenylamine 
• 1400220-48-5 1-[2-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-3-(4-chlorophenyl)-urea 
• 1416013-61-0 (E)-N-(3-bromo-2-fluorophenyl)-2-(hydroxyimino)acetamide 
• 1416013-62-1 2-amino-4-bromo-3-fluorobenzoic acid 
• 1269233-04-6 N-(3-bromo-2-fluorophenyl)propane-1-sulfonamide 

Relevant articles and documents

Preparation and application of indolizine compound

The invention provides an indolizine compound for inhibiting a CBP/EP300Bromodomain receptor as well as a preparation method and application of the indolizine compound. The indolizine compound has a structure as shown in a formula I; the indolizine compound provided by the invention can be effectively combined with a CBP/EP300 bromodomain, and has good selectivity on other bromodomain family proteins; meanwhile, the indolizine compound provided by the invention is more stable in structure.

Indolizine compound as well as preparation method and application thereof

The invention provides an indolizine compound as well as a preparation method and application thereof. The indolizine compound has a structure as shown in a formula I or a formula II, the indolizine compound can be effectively combined with a CBP/EP300 bromine structural domain, the inhibition rate can generally reach 90% or above, the indolizine compound has a good effect and has good selectivityon other bromine structural domain family proteins; moreover, the indolizine compound is stable in structure, and the synthesis method is simpler.

Quinazoline compound and application thereof in medicine (by machine translation)

The invention relates to a quinazoline compound (shown in the formula I) and a medicinal salt thereof, which can be used for treating cancer. The invention also relates to a preparation method and a pharmaceutical composition containing the compounds. (by machine translation)