(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate
CAS No.:1221235-92-2
Molecular Formula:C₃₃H₄₈Cl₂N₄O₆Si
Molecular Weight:695.759
Hs Code.:

Synonyms:(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

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Chemical Property of (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

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Technology Process of (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

There total 11 articles about (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 994-30-9
triethylsilyl chloride

: 1221235-91-1
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

: 1221235-92-2
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Guidance literature:: triethylsilyl chloride; (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

With sodium hydrogencarbonate; In N,N-dimethyl-formamide;

Reference yield:

: 6967-12-0
6-amino-1H-indazole

: 1221235-92-2
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium nitrite; tetrafluoroboric acid / water / 0.67 h / 0 °C

1.2: 0.5 h / 50 - 130 °C

2.1: sodium hydroxide; water / ethanol / 1 h / 20 °C

2.2: pH ~ 7

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4.1: N-chloro-succinimide; potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / dmap / tetrahydrofuran / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

7.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C

8.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water; methanol / 1.17 h / 20 °C / Inert atmosphere

9.1: isopropyl alcohol / Reflux

10.1: hydrogen / CM-101 / tetrahydrofuran; methanol / 20 °C

11.1: hydrogenchloride; triethylamine; hydrogen / ethanol; water / 0.33 h / 20 °C

11.3: 72 h / 20 °C

12.1: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 20 °C

With 1H-imidazole; hydrogenchloride; N-chloro-succinimide; tetrafluoroboric acid; diamide; potassium tert-butylate; tetrabutyl ammonium fluoride; water; hydrogen; triethylamine; triphenylphosphine; sodium hydroxide; sodium nitrite; dmap; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 23244-88-4
1H-indazol-6-ol

: 1221235-92-2
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-(triethylsilyloxy)ethyl)(tert-butoxycarbonyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: N-chloro-succinimide; potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / dmap / tetrahydrofuran / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C

6.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water; methanol / 1.17 h / 20 °C / Inert atmosphere

7.1: isopropyl alcohol / Reflux

8.1: hydrogen / CM-101 / tetrahydrofuran; methanol / 20 °C

9.1: hydrogenchloride; triethylamine; hydrogen / ethanol; water / 0.33 h / 20 °C

9.3: 72 h / 20 °C

10.1: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 20 °C

With 1H-imidazole; hydrogenchloride; N-chloro-succinimide; diamide; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; dmap; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;