DL-Histidine, hydrochloride

Base Information

• Chemical Name: DL-Histidine, hydrochloride
• CAS No.: 6459-59-2
• Molecular Formula: C6H9N3O2^.HCl
• Molecular Weight: 191.617
• Hs Code.: HISTIDINE HCl, MONOHYDRATE PRODUCT IDENTIFICATION
• Mol file: 6459-59-2.mol

Synonyms:DL-Histidine, hydrochloride;C6H9N3O2.ClH;C6-H9-N3-O2.Cl-H

Chemical Property of DL-Histidine, hydrochloride

Chemical Property:

• Appearance/Colour: white crystalline powder
• Melting Point: 233 °C
• Boiling Point: 458.9 °C at 760 mmHg
• Flash Point: 231.3 °C
• PSA: 92.00000
• LogP: 0.86640
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 191.0461543
• Heavy Atom Count: 12
• Complexity: 151

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-3-(1H-imidazol-4-yl)propanoicacidhydrochloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].C1=C(NC=N1)CC(C(=O)O)N.[Cl-]

Technology Process of DL-Histidine, hydrochloride

There total 1 articles about DL-Histidine, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-histidine monohydrochloride (645-35-2) → histidine hydrochloride (6459-59-2)

Guidance literature:

salicylaldehyde; In acetic acid; at 100 ℃; for 1h;

DOI:10.1021/jo00154a019

Reference yield: 100.0%

4-fluorobenzaldehyde (459-57-4) + 2-amino-3-(3H-imidazol-4-yl)propanoic acid hydrochloride (6459-59-2) → C13H12FN3O2 (782441-07-0)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 1h; Reagent/catalyst; Reflux;

DOI:10.1055/s-0033-1340462

Reference yield: 91.0%

2-Fluorobenzaldehyde (446-52-6) + 2-amino-3-(3H-imidazol-4-yl)propanoic acid hydrochloride (6459-59-2) → C13H12FN3O2 (1048031-77-1)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 1h; Reagent/catalyst; Reflux;

DOI:10.1055/s-0033-1340462

upstream raw materials:

L-histidine monohydrochloride

Downstream raw materials:

DL-2-(4-chlorobenzyl)amino-3-(4-imidazolyl)propionic acid

L-histidine monohydrochloride

D-histidine monohydrochloride

4-cyanomethylimidazole

Refernces