8-Chloro-2-(2-chloro-ethyl)-6-phenyl-2,4-dihydro-2,3,5,10b-tetraaza-benzo[e]azulen-1-one

Base Information

Chemical Name:8-Chloro-2-(2-chloro-ethyl)-6-phenyl-2,4-dihydro-2,3,5,10b-tetraaza-benzo[e]azulen-1-one
CAS No.:72874-15-8
Molecular Formula:C₁₈H₁₄Cl₂N₄O
Molecular Weight:373.241
Hs Code.:

Synonyms:8-Chloro-2-(2-chloro-ethyl)-6-phenyl-2,4-dihydro-2,3,5,10b-tetraaza-benzo[e]azulen-1-one

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Chemical Property of 8-Chloro-2-(2-chloro-ethyl)-6-phenyl-2,4-dihydro-2,3,5,10b-tetraaza-benzo[e]azulen-1-one

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Technology Process of 8-Chloro-2-(2-chloro-ethyl)-6-phenyl-2,4-dihydro-2,3,5,10b-tetraaza-benzo[e]azulen-1-one

There total 4 articles about 8-Chloro-2-(2-chloro-ethyl)-6-phenyl-2,4-dihydro-2,3,5,10b-tetraaza-benzo[e]azulen-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4547-02-8
7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-thione

: 72874-15-8
8-Chloro-2-(2-chloro-ethyl)-6-phenyl-2,4-dihydro-2,3,5,10b-tetraaza-benzo[e]azulen-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / ethanol / 24 h / Heating

2: 64.4 percent / 0.25 h / 197 - 207 °C

3: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, xylene, RT, 18 h

With sodium hydride; In ethanol;
DOI:10.1021/jm00178a010

Reference yield:

: 39667-62-4
1-bromo-8-chloro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepine

: 72874-15-8
8-Chloro-2-(2-chloro-ethyl)-6-phenyl-2,4-dihydro-2,3,5,10b-tetraaza-benzo[e]azulen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 80.6 percent / 85percent aq. H₃PO₄ / 6.67 h / 118 - 121 °C

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, xylene, RT, 18 h

With phosphoric acid; sodium hydride;
DOI:10.1021/jm00178a010

Reference yield:

: 31262-81-4
3-(7-chloro-5-phenyl-3H-1,4-benzodiazepin-2-yl)carbazic acid ethyl ester

: 72874-15-8
8-Chloro-2-(2-chloro-ethyl)-6-phenyl-2,4-dihydro-2,3,5,10b-tetraaza-benzo[e]azulen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 64.4 percent / 0.25 h / 197 - 207 °C

2: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, xylene, RT, 18 h

With sodium hydride;
DOI:10.1021/jm00178a010