39667-62-4

Upstream product

• 29975-16-4 estazolam 
• 62893-27-0 N-[4-(2-benzoyl-4-chloro-phenyl)-5-bromo-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide 
• 54485-85-7 N-[4-(2-benzoyl-4-chloro-phenyl)-4H-[1,2,4]triazol-3-ylmethyl]-phthalimide 
• 27610-14-6 3-amino-6-chloro-3,4-dihydro-4-hydroxy-4-phenylquinazoline 
• 59010-35-4 1,3-Dioxo-2-isoindolineacetic Acid, <methylene>hydrazine 

Downstream Products

• 56910-08-8 8-chloro-1-(4-methylpiperazino)-6-phenyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 88701-67-1 8-chloro-1-<4-(2-methoxyethyl)piperazino>-6-phenyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine 
• 31262-82-5 8-chloro-2,4-dihydro-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepin-1-one 
• 36111-54-3 8-chloro-2-(3-dimethylamino-propyl)-6-phenyl-2,4-dihydro-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-one 
• 36111-52-1 8-chloro-2-(2-dimethylamino-ethyl)-6-phenyl-2,4-dihydro-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-1-one 
• 42603-12-3 8-chloro-6-phenyl-2,4-dihydro-2-<2-(diethylamino)ethyl>-1H-s-triazolo<4,3-a><1,4>benzodiazepin-1-one 
• 72874-15-8 8-Chloro-2-(2-chloro-ethyl)-6-phenyl-2,4-dihydro-2,3,5,10b-tetraaza-benzo[e]azulen-1-one 
• 72874-14-7 8-chloro-2,4-dihydro-2-<2-(4-methyl-1-piperazinyl)ethyl>-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepin-1-one 
• 43057-26-7 8-chloro-2,4-dihydro-2-methyl-6-phenyl-1H-s-triazolo<4,3-a><1,4>benzodiazepin-1-one 
• 88176-69-6 8-Chloro-6-phenyl-1-thiomorpholino-4H-s-triazolo[4,3-a][1,4]benzodiazepine 
• 71368-60-0 8-chloro-1-morpholin-4-yl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine 

Relevant academic research and scientific papers

Novel synthesis of the pharmacologically important 1-substituted-6-phenyl-4H-s-triazolo[4,3-α][1,4]benzodiazepines

Several 6-phenyl-4H-s-triazolo[4,3-α][1,4]benzodiazepines have useful biological activity both in experimental animals and in man. This manuscript describes a novel synthesis of these compounds from intermediates that do not have a pre-formed benzodiazepine ring system.

Process for preparing halo triazolo benzodiazepine

Preparing 1-halo-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines by reacting an N-halosuccinimide with a 2-[3-(phthalimidomethyl)triazolyl]benzophenone to form the 2-[5-halo-3-(phthalimidomethyl)triazolyl] benzophenone and reacting the 2-[5-halo-3-(phthalimidomethyl)triazol-4-yl]benzophenone with hydrazine or a primary amine in an organic liquid solvent medium at 25° to 100° C. The products of the process have CNS tranquilizer and sedative properties but are also of interest for use as intermediates to prepare 2,4-dihydro-6-phenyl-1H-s-triazolo[4,3-a] [1,4]benzodiazepin-1-ones which are of clinical interest for their CNS tranquilizer, sedative and anti-depressant drug use properties in mammalian animals including humans.