diethyl 2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)-3-oxopentanedioate

Base Information

Chemical Name:diethyl 2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)-3-oxopentanedioate
CAS No.:888324-78-5
Molecular Formula:C₂₄H₃₈O₆Si
Molecular Weight:450.648
Hs Code.:

Synonyms:diethyl 2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)-3-oxopentanedioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)-3-oxopentanedioate

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Technology Process of diethyl 2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)-3-oxopentanedioate

There total 7 articles about diethyl 2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)-3-oxopentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 951776-91-3
[2-(2-bromo-ethyl)-benzyloxy]-tert-butyl-dimethyl-silane

: 105-50-0
diethyl 1,3-acetonedicarboxylate

: 888324-78-5
diethyl 2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)-3-oxopentanedioate

Guidance literature:: [2-(2-bromo-ethyl)-benzyloxy]-tert-butyl-dimethyl-silane; diethyl 1,3-acetonedicarboxylate; With sodium hydride; In tetrahydrofuran;

With sodium iodide; In acetonitrile; at 60 ℃; for 162h;
DOI:10.1021/ol0604264

Reference yield:

: 888324-77-4
2-[2-((tert-butyldimethylsilanyloxy)methyl)phenyl]ethanol

: 888324-78-5
diethyl 2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)-3-oxopentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 93 percent / LiBr; Et₃N; methanesulfonyl chloride / tetrahydrofuran / 144 h / 20 °C

2.1: NaH / tetrahydrofuran

2.2: 84 percent / NaI / acetonitrile / 162 h / 60 °C

With sodium hydride; methanesulfonyl chloride; triethylamine; lithium bromide; In tetrahydrofuran;
DOI:10.1021/ol0604264

Reference yield:

: {2-[2-(4-methoxy-benzyloxy)-ethyl]-phenyl}-methanol

: 888324-78-5
diethyl 2-(2-((tert-butyldimethylsilyloxy)methyl)phenethyl)-3-oxopentanedioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / imidazole / dimethylformamide / 23 h / 20 °C

2.1: 85 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 2.5 h / 20 °C

3.1: 93 percent / LiBr; Et₃N; methanesulfonyl chloride / tetrahydrofuran / 144 h / 20 °C

4.1: NaH / tetrahydrofuran

4.2: 84 percent / NaI / acetonitrile / 162 h / 60 °C

With 1H-imidazole; sodium hydride; methanesulfonyl chloride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium bromide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol0604264