4-chloro-2-[(1,3-dioxo-1,3-dihydroisobenzofuran-5-carbonyl)amino]benzoic acid

Base Information

• Chemical Name: 4-chloro-2-[(1,3-dioxo-1,3-dihydroisobenzofuran-5-carbonyl)amino]benzoic acid
• CAS No.: 1235866-67-7
• Molecular Formula: C₁₆H₈ClNO₆
• Molecular Weight: 345.696

Synonyms:4-chloro-2-[(1,3-dioxo-1,3-dihydroisobenzofuran-5-carbonyl)amino]benzoic acid

Chemical Property of 4-chloro-2-[(1,3-dioxo-1,3-dihydroisobenzofuran-5-carbonyl)amino]benzoic acid

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Technology Process of 4-chloro-2-[(1,3-dioxo-1,3-dihydroisobenzofuran-5-carbonyl)amino]benzoic acid

There total 1 articles about 4-chloro-2-[(1,3-dioxo-1,3-dihydroisobenzofuran-5-carbonyl)amino]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

trimellitic anhydride acid chloride (1204-28-0) + 2-Amino-4-chlorobenzoic acid (89-77-0) → 4-chloro-2-[(1,3-dioxo-1,3-dihydroisobenzofuran-5-carbonyl)amino]benzoic acid (1235866-67-7)

Guidance literature:

In tetrahydrofuran; at 0 ℃;

DOI:10.1021/jm100442u

Reference yield: 84.0%

4-chloro-2-[(1,3-dioxo-1,3-dihydroisobenzofuran-5-carbonyl)amino]benzoic acid (1235866-67-7) + m-Hydroxyaniline (591-27-5) → 4-chloro-2-([2-(3-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl]amino)benzoic acid (1235866-47-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; toluene; at 130 ℃; for 18h;

DOI:10.1021/jm100442u

Reference yield: 73.0%

4-chloro-2-[(1,3-dioxo-1,3-dihydroisobenzofuran-5-carbonyl)amino]benzoic acid (1235866-67-7) + 2-amino-phenol (95-55-6) → 4-chloro-2-([2-(2-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl]amino)benzoic acid (1235866-46-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; toluene; at 130 ℃; for 18h;

DOI:10.1021/jm100442u

upstream raw materials:

trimellitic anhydride acid chloride

2-Amino-4-chlorobenzoic acid

Downstream raw materials:

4-chloro-2-([2-(2-hydroxymethylphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl]amino)benzoic acid

4-chloro-2-([1,3-dioxo-2-pyridin-3-ylmethyl-2,3-dihydro-1H-isoindole-5-carbonyl]-amino)benzoic acid

4-chloro-2-([1,3-dioxo-2-(1,2,3,4-tetrahydronaphthalen-1-yl)-2,3-dihydro-1H-isoindole-5-carbonyl]-amino)benzoic acid

4-chloro-2-([2-(4-hydroxymethylphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl]amino)benzoic acid

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