2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid

Base Information

Chemical Name:2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid
CAS No.:244089-25-6
Molecular Formula:C₅₅H₄₇N₅O₉
Molecular Weight:922.006
Hs Code.:

Synonyms:2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid

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Chemical Property of 2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid

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Technology Process of 2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid

There total 10 articles about 2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350697-56-2
Benzyl 2-{[2,6-bis(N-tert-butoxycarbonyl-L-phenylalanylamino)-4-pyridyl]oxy} acetate

: 244089-25-6
2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / CH₂Cl₂ / 0.5 h / 20 °C

2: 39 percent / aq. Na₂CO₃ / dioxane / 15 h / 20 °C

3: 60 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 1 h / 20 °C

With hydrogen; sodium carbonate; 10percent Pd/C; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

Reference yield:

: 350697-55-1
{1-[6-(2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-4-hydroxy-pyridin-2-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

: 244089-25-6
2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / K₂CO₃ / dimethylformamide / 15 h / 20 °C

2: 51 percent / CH₂Cl₂ / 0.5 h / 20 °C

3: 39 percent / aq. Na₂CO₃ / dioxane / 15 h / 20 °C

4: 60 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 1 h / 20 °C

With hydrogen; sodium carbonate; potassium carbonate; 10percent Pd/C; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

Reference yield:

: 244089-24-5
4-Benzyloxy-2,6-bis(N-tert-butoxycarbonyl-L-phenylalaninylamino)pyridine

: 244089-25-6
2-{2,6-Bis[N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-4-pyridyloxy} acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Heating

2: 75 percent / K₂CO₃ / dimethylformamide / 15 h / 20 °C

3: 51 percent / CH₂Cl₂ / 0.5 h / 20 °C

4: 39 percent / aq. Na₂CO₃ / dioxane / 15 h / 20 °C

5: 60 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 1 h / 20 °C

With hydrogen; ammonium formate; sodium carbonate; potassium carbonate; 10percent Pd/C; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7