4-Benzyloxy-2,6-diaminopyridine

Base Information

• Chemical Name: 4-Benzyloxy-2,6-diaminopyridine
• CAS No.: 18986-54-4
• Molecular Formula: C12H13N3O
• Molecular Weight: 215.255
• DSSTox Substance ID: DTXSID60476944
• Nikkaji Number: J1.198.938A
• Wikidata: Q82308907
• Mol file: 18986-54-4.mol

Synonyms:18986-54-4;AGN-PC-0NHOR0;SCHEMBL15305717;4-benzyloxy-2,6-diaminopyridine;DTXSID60476944

Chemical Property of 4-Benzyloxy-2,6-diaminopyridine

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 215.105862047
• Heavy Atom Count: 16
• Complexity: 196

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC(=NC(=C2)N)N

Technology Process of 4-Benzyloxy-2,6-diaminopyridine

There total 11 articles about 4-Benzyloxy-2,6-diaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-benzyloxy-2,6-pyridinedicarboxamide (350697-54-0) → 4?benzyloxy?2,6?diaminopyridine (18986-54-4)

Guidance literature:

With potassium hydroxide; bromine; at 90 ℃; for 5h;

DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

Reference yield: 58.5%

4?benzyloxy?2,6?dicarboethoxyamino pyridine (18986-39-5) → 4?benzyloxy?2,6?diaminopyridine (18986-54-4)

Guidance literature:

With potassium hydroxide; In ethanol; for 12h; Reflux;

DOI:10.1007/s12149-019-01341-0

Reference yield:

dibenzyl 4-(benzyloxy)-2,6-pyridinedicarboxylate (99097-41-3) → 4?benzyloxy?2,6?diaminopyridine (18986-54-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / NH₃ / methanol / 3 h / 20 °C

2: 76 percent / aq. KOH; Br₂ / 5 h / 90 °C

With potassium hydroxide; ammonia; bromine; In methanol;

DOI:10.1002/1521-3765(20010504)7:9<1889::AID-CHEM1889>3.0.CO;2-7

upstream raw materials:

4-benzyloxy-2,6-pyridinedicarboxamide

4?benzyloxy?2,6?dicarboethoxyamino pyridine

benzyl bromide

4?benzyloxy pyridine?2,6?dicarboxylic acid dihydrazide

Downstream raw materials:

2,6-bis(hexanoylamino)-4-benzyloxypyridine

6?amino?2?(4?fluorophenyl)?4?benzyloxy?3?(4?pyridyl)?1H-pyrrolo[2,3?b]pyridine

di-tert-butyl(4-(benzyloxy)pyridine-2,6-diyl)bis(tert-butoxycarbonylcarbamate)

4-Benzyloxy-2,6-bis(N-tert-butoxycarbonyl-L-phenylalaninylamino)pyridine