4-[prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol

Base Information

Chemical Name:4-[prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol
CAS No.:299949-07-8
Molecular Formula:C₂₅H₃₄N₄O
Molecular Weight:406.571
Hs Code.:

Synonyms:4-[prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol

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Chemical Property of 4-[prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol

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Technology Process of 4-[prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol

There total 1 articles about 4-[prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 4-chloro-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidine

: 87834-82-0
4-(prop-2-enylamino)butan-1-ol

: 299949-07-8
4-[prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol

Guidance literature:: In dimethyl sulfoxide; at 130 ℃; for 6h;
DOI:10.1002/1099-1344(200008)43:9<899::AID-JLCR375>3.0.CO;2-N

Reference yield: 79.0%

: 299949-07-8
4-[prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol

: but-3-enylprop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine

: 299949-04-5
(4-fluorobutyl)prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine

Guidance literature:: With 4 A molecular sieve; p-toluenesulfonyl fluoride; tetrabutyl ammonium fluoride; In tetrahydrofuran; for 20h; Heating;
DOI:10.1002/1099-1344(200008)43:9<899::AID-JLCR375>3.0.CO;2-N

Reference yield:

: 299949-07-8
4-[prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol

: (4-fluorobutyl)propyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-pyrrolo[2,3-d]pyrimidin-4-yl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / TBAF; TsF; molecular sieves 4 Angstroem / tetrahydrofuran / 20 h / Heating

2: 98 percent / H₂ / Pd/C / ethanol / 16 h / 20 °C / 760 Torr

With 4 A molecular sieve; p-toluenesulfonyl fluoride; tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; 1: Substitution / 2: Catalytic hydrogenation;
DOI:10.1002/1099-1344(200008)43:9<899::AID-JLCR375>3.0.CO;2-N