(4-fluorobutyl)prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine

Base Information

Chemical Name:(4-fluorobutyl)prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine
CAS No.:299949-04-5
Molecular Formula:C₂₅H₃₃FN₄
Molecular Weight:408.562
Hs Code.:

Synonyms:(4-fluorobutyl)prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine

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Chemical Property of (4-fluorobutyl)prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine

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Technology Process of (4-fluorobutyl)prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine

There total 2 articles about (4-fluorobutyl)prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 299949-07-8
4-[prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]butan-1-ol

: but-3-enylprop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine

: 299949-04-5
(4-fluorobutyl)prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine

Guidance literature:: With 4 A molecular sieve; p-toluenesulfonyl fluoride; tetrabutyl ammonium fluoride; In tetrahydrofuran; for 20h; Heating;
DOI:10.1002/1099-1344(200008)43:9<899::AID-JLCR375>3.0.CO;2-N

Reference yield:

: 87834-82-0
4-(prop-2-enylamino)butan-1-ol

: 299949-04-5
(4-fluorobutyl)prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / dimethylsulfoxide / 6 h / 130 °C

2: 79 percent / TBAF; TsF; molecular sieves 4 Angstroem / tetrahydrofuran / 20 h / Heating

With 4 A molecular sieve; p-toluenesulfonyl fluoride; tetrabutyl ammonium fluoride; In tetrahydrofuran; dimethyl sulfoxide; 1: Substitution / 2: Substitution;
DOI:10.1002/1099-1344(200008)43:9<899::AID-JLCR375>3.0.CO;2-N

Reference yield: 98.0%

: 299949-04-5
(4-fluorobutyl)prop-2-enyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine

: (4-fluorobutyl)propyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)-pyrrolo[2,3-d]pyrimidin-4-yl]amine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 16h; under 760 Torr;
DOI:10.1002/1099-1344(200008)43:9<899::AID-JLCR375>3.0.CO;2-N