1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-[3-(trifluoromethyl)phenyl]-1H-benzimidazole

Base Information

• Chemical Name: 1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-[3-(trifluoromethyl)phenyl]-1H-benzimidazole
• CAS No.: 1108147-82-5
• Molecular Formula: C₂₈H₃₄F₃N₃
• Molecular Weight: 469.593
• Mol file: 1108147-82-5.mol

Synonyms:1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-[3-(trifluoromethyl)phenyl]-1H-benzimidazole

Chemical Property of 1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-[3-(trifluoromethyl)phenyl]-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-[3-(trifluoromethyl)phenyl]-1H-benzimidazole

There total 1 articles about 1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-[3-(trifluoromethyl)phenyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

N-[1-(1-methylcyclooctyl)-4-piperidinyl]-1,2-benzenediamine (1108147-58-5) + 3-(Trifluoromethyl)benzoyl chloride (2251-65-2) → 1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-[3-(trifluoromethyl)phenyl]-1H-benzimidazole (1108147-82-5)

Guidance literature:

N-[1-(1-methylcyclooctyl)-4-piperidinyl]-1,2-benzenediamine; 3-(Trifluoromethyl)benzoyl chloride; With pyridine; at 20 ℃; Inert atmosphere;

With phosphoryl trichloride; for 4.5h; Inert atmosphere; Reflux;

DOI:10.1021/jm7012979

Reference yield:

1-[1-(1-methylcyclooctyl)piperidin-4-yl]-2-[3-(trifluoromethyl)phenyl]-1H-benzimidazole (1108147-82-5) → C28H34F3N3*2ClH

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm7012979

upstream raw materials:

N-[1-(1-methylcyclooctyl)-4-piperidinyl]-1,2-benzenediamine

3-(Trifluoromethyl)benzoyl chloride