(2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)(pyrrolidin-1-yl)methanone

Base Information

Chemical Name:(2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)(pyrrolidin-1-yl)methanone
CAS No.:1569982-13-3
Molecular Formula:C₂₂H₂₁ClN₄O₂
Molecular Weight:408.887
Hs Code.:

Synonyms:(2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)(pyrrolidin-1-yl)methanone

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Chemical Property of (2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)(pyrrolidin-1-yl)methanone

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Technology Process of (2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)(pyrrolidin-1-yl)methanone

There total 5 articles about (2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)(pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 123-75-1
pyrrolidine

: 1569982-08-6
ethyl 2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)benzoate

: 1569982-13-3
(2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: at 50 ℃; for 120h;

Reference yield:

: 16588-17-3
ethyl ester of 2-chloro-5-nitrobenzoic acid

: 1569982-13-3
(2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride dihdyrate; hydrogenchloride / ethanol / 24 h / 20 °C

2: triethylamine / isopropyl alcohol / 120 h / Reflux

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / ethanol / 168 h / Inert atmosphere; Reflux

4: 120 h / 50 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; triethylamine; In ethanol; isopropyl alcohol;

Reference yield:

: 1569986-10-2
2-chloro-5-(6-chloro-pyrimidin-4-ylamino)-benzoic acid ethyl ester

: 1569982-13-3
(2-chloro-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / ethanol / 168 h / Inert atmosphere; Reflux

2: 120 h / 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In ethanol;