ethyl 1-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}-5-chloro-3-[({[3-(methyloxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate

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Chemical Name:ethyl 1-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}-5-chloro-3-[({[3-(methyloxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate
CAS No.:1398118-21-2
Molecular Formula:C₂₆H₂₄ClN₅O₅S
Molecular Weight:554.026
Hs Code.:

Synonyms:ethyl 1-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}-5-chloro-3-[({[3-(methyloxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate

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Chemical Property of ethyl 1-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}-5-chloro-3-[({[3-(methyloxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate

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Technology Process of ethyl 1-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}-5-chloro-3-[({[3-(methyloxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate

There total 7 articles about ethyl 1-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}-5-chloro-3-[({[3-(methyloxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: ethyl 1-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}-3-amino-5-chloro-1H-pyrrole-2-carboxylate trifluroacetate

: 18908-07-1
3-methoxyphenyl isocyanate

: 1398118-21-2
ethyl 1-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}-5-chloro-3-[({[3-(methyloxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate

Guidance literature:: In toluene; at 80 ℃;

Reference yield:

: 252932-49-3
3-amino-2-ethoxycarbonylpyrrole hydrochloride

: 1398118-21-2
ethyl 1-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}-5-chloro-3-[({[3-(methyloxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dmap / 0 - 20 °C

2: N-chloro-succinimide / tetrahydrofuran / 17 h / 30 °C

3: triethylamine; copper diacetate; oxygen / dichloromethane; isopropyl alcohol / 48 h / 20 °C

4: dichloromethane / 20 °C

5: toluene / 80 °C

With pyridine; N-chloro-succinimide; oxygen; copper diacetate; triethylamine; dmap; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene;

Reference yield:

: 53173-91-4
2-(N-acetamino)-4-(4-bromophenyl)thiazole

: 1398118-21-2
ethyl 1-{4-[2-(acetylamino)-1,3-thiazol-4-yl]phenyl}-5-chloro-3-[({[3-(methyloxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 17 h / 100 °C / Inert atmosphere

2: sodium periodate; water; ammonium acetate / acetone / 60 h / 20 °C

3: triethylamine; copper diacetate; oxygen / dichloromethane; isopropyl alcohol / 48 h / 20 °C

4: dichloromethane / 20 °C

5: toluene / 80 °C

With sodium periodate; ammonium acetate; water; oxygen; potassium acetate; copper diacetate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; isopropyl alcohol; acetone; toluene;