2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoic acid

Base Information

• Chemical Name: 2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoic acid
• CAS No.: 1018069-85-6
• Molecular Formula: C₁₆H₁₂F₃NO₃
• Molecular Weight: 323.271
• Mol file: 1018069-85-6.mol

Synonyms:2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoic acid

Chemical Property of 2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoic acid

There total 2 articles about 2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoate (1018070-64-8) → 2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoic acid (1018069-85-6)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 20h;

DOI:10.1021/jm7010996

Reference yield: 71.0%

3-iodo-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide (884600-93-5) + carbon dioxide (124-38-9,18923-20-1) → 2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoic acid (1018069-85-6)

Guidance literature:

With isopropylmagnesium bromide; In tetrahydrofuran; at -20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm4017762

Reference yield: 91.0%

N2-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-2,5-diamine (925897-77-4) + 2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoic acid (1018069-85-6) → 4-methyl-N3-(2-(4-(4-methyl-piperazin-1-yl)phenylamino)pyrimidin-5-yl)-N1-(3-(trifluoromethyl)phenyl)isophthalamide

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;

DOI:10.1021/jm7010996

upstream raw materials:

methyl 2-methyl-5-((3-(trifluoromethyl)phenyl)carbamoyl)benzoate

3-iodo-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

carbon dioxide

Downstream raw materials:

N³-(2-(3-aminophenylamino)pyrimidin-5-yl)-4-methyl-N₁-(3-(trifluoromethyl)phenyl)isophthalamide