Technology Process of (S)-tert-butyl-2-(tritylamino)-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate
There total 8 articles about (S)-tert-butyl-2-(tritylamino)-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / toluene / 3 h / -78 - -35 °C / Inert atmosphere
3.1: zinc; iodine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
3.2: organozinc reagent / 20 °C / Inert atmosphere
4.1: morpholine / N,N-dimethyl-formamide / 1 h / 20 °C
5.1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
With
morpholine; tetrabutyl-ammonium chloride; iodine; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc;
In
dichloromethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tert.-butylhydroperoxide; potassium iodide / acetonitrile; water / 110 °C
2.1: boron tribromide / dichloromethane / 0.5 h / -78 °C
3.1: tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
4.1: diisobutylaluminium hydride / toluene / 3 h / -78 - -35 °C / Inert atmosphere
5.1: zinc; iodine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
5.2: organozinc reagent / 20 °C / Inert atmosphere
6.1: morpholine / N,N-dimethyl-formamide / 1 h / 20 °C
7.1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
With
morpholine; tert.-butylhydroperoxide; tetrabutyl-ammonium chloride; iodine; boron tribromide; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; zinc;
In
dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
