(S)-tert-butyl-2-amino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

Base Information

Chemical Name:(S)-tert-butyl-2-amino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate
CAS No.:1614253-56-3
Molecular Formula:C₁₆H₂₄N₂O₇
Molecular Weight:356.376
Hs Code.:

Synonyms:(S)-tert-butyl-2-amino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-tert-butyl-2-amino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

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Technology Process of (S)-tert-butyl-2-amino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

There total 7 articles about (S)-tert-butyl-2-amino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: (S)-tert-butyl-2-(9H-fluorenylmethoxycarbonylamino)-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

: 1614253-56-3
(S)-tert-butyl-2-amino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

Guidance literature:: With morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield: 91.0%

: 1614253-55-2
(S)-tert-butyl-2-(9H-fluoren-9ylmethoxy)carbonylamino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

: 1614253-56-3
(S)-tert-butyl-2-amino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

Guidance literature:: With morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 137832-56-5
methyl 4-amino-5-iodo-2-methoxybenzoate

: 1614253-56-3
(S)-tert-butyl-2-amino-3-(5-hydroxymethyl-4-methoxymethoxy-2-nitro-phenyl)-propionate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tert.-butylhydroperoxide; potassium iodide / acetonitrile; water / 110 °C

2.1: boron tribromide / dichloromethane / 0.5 h / -78 °C

3.1: tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / toluene / 3 h / -78 - -35 °C / Inert atmosphere

5.1: zinc; iodine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

5.2: organozinc reagent / 20 °C / Inert atmosphere

6.1: morpholine / N,N-dimethyl-formamide / 1 h / 20 °C

With morpholine; tert.-butylhydroperoxide; tetrabutyl-ammonium chloride; iodine; boron tribromide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; potassium iodide; zinc; In dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;