4-[¹⁸F]fluorobenzoic acid

Base Information

• Chemical Name: 4-[¹⁸F]fluorobenzoic acid
• CAS No.: 10011-97-9
• Molecular Formula: C₇H₅FO₂
• Molecular Weight: 139.115
• Mol file: 10011-97-9.mol

Synonyms:4-[¹⁸F]fluorobenzoic acid

Chemical Property of 4-[¹⁸F]fluorobenzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[¹⁸F]fluorobenzoic acid

There total 15 articles about 4-[¹⁸F]fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-(N,N,N-trimethylammonium)-1-benzoate triflate (124915-06-6) → 4-[18F]fluorobenzoic acid (10011-97-9)

Guidance literature:

ethyl 4-(N,N,N-trimethylammonium)-1-benzoate triflate; With [18F]fluoride ion, cyclotron produced, NCA;

With sodium hydroxide; Further stages.;

DOI:10.1021/jm7014765

Reference yield:

ethyl 4-[18F]fluorobenzoate (124915-09-9) → 4-[18F]fluorobenzoic acid (10011-97-9)

Guidance literature:

With sodium hydroxide; at 80 ℃; for 0.0833333h;

Reference yield:

4-[1,1-dimethylethyl ester]-N,N,N-trimethyl-benzenammonium triflate → 4-[18F]fluorobenzoic acid (10011-97-9)

Guidance literature:

4-[1,1-dimethylethyl ester]-N,N,N-trimethyl-benzenammonium triflate; With [18F]-tetrabutylammonium fluoride; In dimethyl sulfoxide; for 0.00833333h; microwave irradiation;

With trifluoroacetic acid; at 90 ℃; for 0.0333333h;

upstream raw materials:

ethyl 4-[18F]fluorobenzoate

4-[18F]fluorobenzaldehyde

2,3,4,5,6-pentamethylbenzyl 4-trimethylammoniobenzoate trifluoromethanesulfonate

4-[18F]fluorobenzonitrile

Downstream raw materials:

N-succinimidyl 4-[18F]fluorobenzoate

[18F]-4-fluorobenzoic acid chloride

N-(6-(1-benzyl-1H-dibenzo[b,f][1,2,3]triazolo[4,5-d]azocin-8(9H)-yl)-6-oxohexyl)-4-[18F]fluorobenzamide

32-(8-(6-(4-[18F]fluorobenzamido)hexanoyl)-8,9-dihydro-1H-dibenzo[b,f][1,2,3]triazolo-[4,5-d]azocin-1-yl)-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontan-1-oic acid

Refernces

• 1、 Davis, Ryan A.,Lau, Kevin,Hausner, Sven H.,Sutcliffe, Julie L.. "Solid-phase synthesis and fluorine-18 radiolabeling of cycloRGDyK". . p. 8659 - 8663. Retrieved 2016.
• 2、 Murakami, Yoshihiro,Nishimura, Shintaro,Noda, Akihiro,Harada, Norihiro,Tsukada, Hideo. "Synthesis of 18F labelled FK960, a candidate anti-dementia drug, and PET studies in conscious monkeys". . p. 1219 - 1228. Retrieved 2002.
• 3、 Hausner, Sven H.,Marik, Jan,Gagnon, M. Karen J.,Sutcliffe, Julie L.. "In vivo positron emission tomography (PET) imaging with an αvβ6 specific peptide radiolabeled using 18F-"click" chemistry: Evaluation and comparison with the corresponding 4-[18F]fluorobenzoyl- and 2-[18 . p. 5901 - 5904. Retrieved 2008.
• 4、 Cheng, Dengfeng,Yin, Duanzhi,Zhang, Lan,Wang, Mingwei,Li, Gucai,Wang, Yongxian. "Preparation of the novel fluorine-18-labeled VIP analog for PET imaging studies using two different synthesis methods". . p. 196 - 201. Retrieved 2007.
• 5、 Xxx. "-". . p. 509 - 520. Retrieved 2001.
• 6、 Lu, Chunxiong,Jiang, Quanfu,Hu, Minjin,Tan, Cheng,Yu, Huixin,Hua, Zichun. "Preliminary biological evaluation of 18F-FBEM-Cys-annexin V a novel apoptosis imaging agent". . p. 4902 - 4914. Retrieved 2015.
• 7、 Sutcliffe-Goulden, Julie L.,O'Doherty, Michael J.,Bansal, Sukhvinder S.. "Solid phase synthesis of [18F]labelled peptides for positron emission tomography". . p. 1501 - 1503. Retrieved 2000.
• 8、 Yang, Wenjiang,Mou, Tiantian,Peng, Cheng,Wu, Zhanhong,Zhang, Xianzhong,Li, Fang,Ma, Yunchuan. "Fluorine-18 labeled galactosyl-neoglycoalbumin for imaging the hepatic asialoglycoprotein receptor". . p. 7510 - 7516. Retrieved 2009.
• 9、 -. "Compound, composition, and method for detecting caspase activity and/or apoptosis". . . Retrieved 2019/06/26.