N-succinimidyl-4-fluorobenzoate

Base Information

• Chemical Name: N-succinimidyl-4-fluorobenzoate
• CAS No.: 141762-27-8
• Molecular Formula: C11H8 F N O4
• Molecular Weight: 236.189
• Mol file: 141762-27-8.mol

Synonyms:2,5-Pyrrolidinedione,1-[[4-(fluoro-18F)benzoyl]oxy]- (9CI); N-Succinimidyl 4-[18F]Fluorobenzoate;[18F]SFB

Chemical Property of N-succinimidyl-4-fluorobenzoate

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 63.68000
• Density: 1.46g/cm³
• LogP: 0.98440

Purity/Quality:

99%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-succinimidyl-4-fluorobenzoate

There total 35 articles about N-succinimidyl-4-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate (105832-38-0) + 4-[18F]fluorobenzoic acid (10011-97-9) → N-succinimidyl 4-[18F]fluorobenzoate (141762-27-8)

Guidance literature:

In acetonitrile; at 90 ℃; for 0.1h;

Reference yield: 32.0%

di(succinimido) carbonate (74124-79-1) + 4-[18F]fluorobenzoic acid (10011-97-9) → N-succinimidyl 4-[18F]fluorobenzoate (141762-27-8)

Guidance literature:

With pyridine; In acetonitrile; at 150 ℃; for 0.0833333h;

DOI:10.3891/acta.chem.scand.52-1034

Reference yield: 23.0%

(4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate (1196658-43-1) → N-succinimidyl 4-[18F]fluorobenzoate (141762-27-8)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium carbonate; [2.2.2]cryptande; In N,N-dimethyl-formamide; at 130 ℃; for 0.0833333h; Inert atmosphere;

upstream raw materials:

di(succinimido) carbonate

4-[¹⁸F]fluorobenzoic acid

O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

tetrapropylammonium 4-[¹⁸F]fluorobenzoate

Downstream raw materials:

N-(6-(1-benzyl-1H-dibenzo[b,f][1,2,3]triazolo[4,5-d]azocin-8(9H)-yl)-6-oxohexyl)-4-[18F]fluorobenzamide

32-(8-(6-(4-[18F]fluorobenzamido)hexanoyl)-8,9-dihydro-1H-dibenzo[b,f][1,2,3]triazolo-[4,5-d]azocin-1-yl)-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontan-1-oic acid

N-(4-(3,5-bis((bis(pyridin-2-ylmethyl)amino)methyl)phenoxy)-n-butyl)-4-[18F]fluorobenzamide

C₂₃H₃₃⁽¹⁸⁾FN₈O₅