2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid

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Chemical Name:2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid
CAS No.:204516-44-9
Molecular Formula:C₄₂H₃₆N₈O₂
Molecular Weight:684.8
Hs Code.:

Synonyms:2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid

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Chemical Property of 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid

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Technology Process of 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid

There total 9 articles about 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 76-83-5
trityl chloride

: 151406-37-0
2,7-diethyl-5-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid

: 204516-44-9
2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.287

Reference yield:

: 161487-34-9
(2,7-Diethyl-1H-pyrazolo[1,5-b][1,2,4]triazol-6-yl)-methanol

: 204516-44-9
2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KOt-Bu / 1.) DMF, 20 min, 2.) DMF, RT, overnight

2: 92 percent / AcOH / methanol / 8 h / Heating

3: 93 percent / Na₂S₂O₈, RuCl₃*nH₂O, aq. KOH

4: 83 percent / Et₃N / dimethylformamide

With ruthenium trichloride; potassium hydroxide; sodium persulfate; potassium tert-butylate; acetic acid; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.287

Reference yield:

: 151521-90-3
3-amino-4-ethyl-5-diethoxymethyl-1H-pyrazole

: 204516-44-9
2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: toluene / 4 h / Heating

2: H₂NOH / methanol / 16 h / Ambient temperature

3: pyridine / N,N-dimethyl-acetamide / 2 h / Ambient temperature

4: pyridine / methanol / 2 h / Heating

5: 92 percent / NaBH₄ / ethanol / 1 h

6: 1.) KOt-Bu / 1.) DMF, 20 min, 2.) DMF, RT, overnight

7: 92 percent / AcOH / methanol / 8 h / Heating

8: 93 percent / Na₂S₂O₈, RuCl₃*nH₂O, aq. KOH

9: 83 percent / Et₃N / dimethylformamide

With pyridine; ruthenium trichloride; potassium hydroxide; sodium tetrahydroborate; sodium persulfate; potassium tert-butylate; hydroxylamine; acetic acid; triethylamine; In methanol; ethanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.46.287