1-ethoxycarbonyloxyethyl 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylate

Base Information

• Chemical Name: 1-ethoxycarbonyloxyethyl 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylate
• CAS No.: 204516-45-0
• Molecular Formula: C₄₇H₄₄N₈O₅
• Molecular Weight: 800.917
• Mol file: 204516-45-0.mol

Synonyms:1-ethoxycarbonyloxyethyl 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylate

Chemical Property of 1-ethoxycarbonyloxyethyl 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethoxycarbonyloxyethyl 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylate

There total 13 articles about 1-ethoxycarbonyloxyethyl 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Chloroethyl ethyl carbonate (50893-36-2) → 1-ethoxycarbonyloxyethyl 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylate (204516-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / acetonitrile / 0.75 h / 60 - 70 °C

2: 1.) KOH / 1.) EtOH, 2.) acetone, RT, 2 d

With potassium hydroxide; sodium iodide; In acetonitrile;

DOI:10.1248/cpb.46.287

Reference yield:

trityl chloride (76-83-5) → 1-ethoxycarbonyloxyethyl 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylate (204516-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / Et₃N / dimethylformamide

2: 1.) KOH / 1.) EtOH, 2.) acetone, RT, 2 d

With potassium hydroxide; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.46.287

Reference yield:

(2,7-Diethyl-1H-pyrazolo[1,5-b][1,2,4]triazol-6-yl)-methanol (161487-34-9) → 1-ethoxycarbonyloxyethyl 2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylate (204516-45-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) KOt-Bu / 1.) DMF, 20 min, 2.) DMF, RT, overnight

2: 92 percent / AcOH / methanol / 8 h / Heating

3: 93 percent / Na₂S₂O₈, RuCl₃*nH₂O, aq. KOH

4: 83 percent / Et₃N / dimethylformamide

5: 1.) KOH / 1.) EtOH, 2.) acetone, RT, 2 d

With ruthenium trichloride; potassium hydroxide; sodium persulfate; potassium tert-butylate; acetic acid; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.46.287

upstream raw materials:

2,7-diethyl-5-[[2'-(N-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]-5H-pyrazolo[1,5-b][1,2,4]triazole-6-carboxylic acid

ethyl 1-iodoethylcarbonate

1-Chloroethyl ethyl carbonate

trityl chloride