(Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene

Base Information

Chemical Name:(Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene
CAS No.:959859-95-1
Molecular Formula:C₁₈H₁₉F₂NO₄
Molecular Weight:351.35
Hs Code.:

Synonyms:(Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene

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Chemical Property of (Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene

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Technology Process of (Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene

There total 5 articles about (Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.6%

: 959860-04-9
(Z)-3,4,5-trimethoxy-4'-difluoromethoxy-3'-nitro-1,2-diphenylethylene

: 959859-95-1
(Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene

Guidance literature:: With water; sodium thiosulfate; In acetone; at 50 ℃; for 6h; Heating / reflux;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 959859-95-1
(Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / 18-crown-6 ether / water; isopropyl alcohol / 0.5 h

1.2: 5 - 6 h / 65 °C

2.1: nitric acid; acetic anhydride / dichloromethane; water / 51 - 52 h / 5 - 20 °C

3.1: tetrahydrofuran / -15 - 20 °C

4.1: water; sodium thiosulfate / acetone / 6 h / 50 °C / Heating / reflux

With sodium hydroxide; water; nitric acid; acetic anhydride; sodium thiosulfate; 18-crown-6 ether; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; acetone; 3.1: Wittig Reaction;

Reference yield:

: 315188-38-6
4-difluoromethoxy-3-nitrobenzaldehyde

: 959859-95-1
(Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -15 - 20 °C

2: water; sodium thiosulfate / acetone / 6 h / 50 °C / Heating / reflux

With water; sodium thiosulfate; In tetrahydrofuran; acetone; 1: Wittig Reaction;