(Z)-1-(3,4,5-trimethoxphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene-3'-N-serinamide

Base Information

Chemical Name:(Z)-1-(3,4,5-trimethoxphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene-3'-N-serinamide
CAS No.:959859-99-5
Molecular Formula:C₂₁H₂₄F₂N₂O₆
Molecular Weight:438.428
Hs Code.:

Synonyms:(Z)-1-(3,4,5-trimethoxphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene-3'-N-serinamide

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Chemical Property of (Z)-1-(3,4,5-trimethoxphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene-3'-N-serinamide

Chemical Property:

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Technology Process of (Z)-1-(3,4,5-trimethoxphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene-3'-N-serinamide

There total 5 articles about (Z)-1-(3,4,5-trimethoxphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene-3'-N-serinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959859-95-1
(Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene

: 171778-17-9,608512-87-4
N^α-(9-fluorenylmethoxycarbonyl)-O-acetyl-L-serine

: 959859-99-5
(Z)-1-(3,4,5-trimethoxphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene-3'-N-serinamide

Guidance literature:: (Z)-1-(3,4,5-trimethoxyphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene; N^α-(9-fluorenylmethoxycarbonyl)-O-acetyl-L-serine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

With sodium hydroxide; water;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 959859-99-5
(Z)-1-(3,4,5-trimethoxphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene-3'-N-serinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / 18-crown-6 ether / water; isopropyl alcohol / 0.5 h

1.2: 5 - 6 h / 65 °C

2.1: nitric acid; acetic anhydride / dichloromethane; water / 51 - 52 h / 5 - 20 °C

3.1: tetrahydrofuran / -15 - 20 °C

4.1: water; sodium thiosulfate / acetone / 6 h / 50 °C / Heating / reflux

5.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide

With sodium hydroxide; water; nitric acid; acetic anhydride; benzotriazol-1-ol; sodium thiosulfate; dicyclohexyl-carbodiimide; 18-crown-6 ether; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; 3.1: Wittig Reaction;

Reference yield:

: 361375-94-2
((3,4,6-trimethoxyphenyl)methylene)triphenylphosphonium bromide

: 959859-99-5
(Z)-1-(3,4,5-trimethoxphenyl)-2-(3'-amino-4'-difluoromethoxyphenyl)-ethene-3'-N-serinamide

Guidance literature:: Multi-step reaction with 4 steps

1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -15 °C

2: tetrahydrofuran / -15 - 20 °C

3: water; sodium thiosulfate / acetone / 6 h / 50 °C / Heating / reflux

4: benzotriazol-1-ol; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide

With n-butyllithium; water; benzotriazol-1-ol; sodium thiosulfate; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone; 2: Wittig Reaction;