4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-benzoic acid methyl ester

Base Information

Chemical Name:4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-benzoic acid methyl ester
CAS No.:217462-57-2
Molecular Formula:C₂₅H₂₇IO₃Si
Molecular Weight:530.478
Hs Code.:

Synonyms:4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-benzoic acid methyl ester

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Chemical Property of 4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-benzoic acid methyl ester

Chemical Property:

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Technology Process of 4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-benzoic acid methyl ester

There total 6 articles about 4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 217461-36-4
3-Amino-4-(tert-butyl-diphenyl-silanyloxymethyl)-benzoic acid methyl ester

: 217462-57-2
4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-benzoic acid methyl ester

Guidance literature:: With iodine; isopentyl nitrite; In benzene; at 100 ℃;
DOI:10.1055/s-1998-1900

Reference yield:

: 6232-88-8
4-bromomethylbenzoic Acid

: 217462-57-2
4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / HNO₃, H₂O / 3 h / -10 °C

2: 91 percent / Na₂CO₃, H₂O / acetone / 12 h / Heating

3: 83 percent / BF₃*OEt₂ / 15 h / Heating

4: 95 percent / DMAP, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

5: 75 percent / Na₂S₂O₄, H₂O / ethanol / 0.5 h / 100 °C

6: 80 percent / iAmONO, I₂ / benzene / 100 °C

With dmap; sodium dithionite; boron trifluoride diethyl etherate; water; iodine; nitric acid; sodium carbonate; triethylamine; isopentyl nitrite; In ethanol; dichloromethane; acetone; benzene;
DOI:10.1055/s-1998-1900

Reference yield:

: 55715-03-2
4-bromomethyl-3-nitrobenzoic acid

: 217462-57-2
4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-iodo-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / Na₂CO₃, H₂O / acetone / 12 h / Heating

2: 83 percent / BF₃*OEt₂ / 15 h / Heating

3: 95 percent / DMAP, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 75 percent / Na₂S₂O₄, H₂O / ethanol / 0.5 h / 100 °C

5: 80 percent / iAmONO, I₂ / benzene / 100 °C

With dmap; sodium dithionite; boron trifluoride diethyl etherate; water; iodine; sodium carbonate; triethylamine; isopentyl nitrite; In ethanol; dichloromethane; acetone; benzene;
DOI:10.1055/s-1998-1900