2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide

Base Information

• Chemical Name: 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide
• CAS No.: 529496-47-7
• Molecular Formula: C₃₀H₃₈N₄O₆S
• Molecular Weight: 582.721

Synonyms:2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide

Chemical Property of 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide

There total 10 articles about 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-benzylhydoxylamine hydrochloride (2687-43-6) + 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid (529496-46-6) → 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide (529496-47-7)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/jm020475w

Reference yield:

3,5-dimethoxybenzaldehdye (7311-34-4) → 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide (529496-47-7)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 5 h / 20 °C

2: 104 mg / sodium borohydride / ethanol / 20 °C

3: trifluoroacetic acid / 1.5 h

4: 74 mg / diisopropylethylamine; BOP reagent / dimethylformamide / 0 - 20 °C

With sodium tetrahydroborate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm020475w

Reference yield:

2,4-dinitrobenzenesulfonyl chloride (1656-44-6) → 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ6-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide (529496-47-7)

Guidance literature:

Multi-step reaction with 8 steps

1: N-methylmorpholine / dioxane / 20 °C

2: diethyl azaodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C

3: Fe; aq. acetic acid / 1.5 h / 60 °C

4: N-methylmorpholine / dimethylformamide / 80 °C

5: ethanol / 5 h / 20 °C

6: 104 mg / sodium borohydride / ethanol / 20 °C

7: trifluoroacetic acid / 1.5 h

8: 74 mg / diisopropylethylamine; BOP reagent / dimethylformamide / 0 - 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; iron; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 2: Mitsunobu reaction;

DOI:10.1021/jm020475w

upstream raw materials:

O-benzylhydoxylamine hydrochloride

2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid

3,5-dimethoxybenzaldehdye

2,4-dinitrobenzenesulfonyl chloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 529496-47-7 2-[7-(3,5-dimethoxy-benzylamino)-1,1-dioxo-1,3,4,5-tetrahydro-1λ⁶-benzo[f][1,2,5]thiadiazepin-2-yl]-4-methyl-pentanoic acid benzyloxy-amide

Send

Send

Metric Ton KG G Pound L ML

Send

Send