[2-(4-fluorophenyl)-1-isopropyl-1H-benzoimidazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

Base Information

Chemical Name:[2-(4-fluorophenyl)-1-isopropyl-1H-benzoimidazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine
CAS No.:1240608-38-1
Molecular Formula:C₂₇H₂₆FN₅O
Molecular Weight:455.535
Hs Code.:

Synonyms:[2-(4-fluorophenyl)-1-isopropyl-1H-benzoimidazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

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Chemical Property of [2-(4-fluorophenyl)-1-isopropyl-1H-benzoimidazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

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Technology Process of [2-(4-fluorophenyl)-1-isopropyl-1H-benzoimidazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

There total 9 articles about [2-(4-fluorophenyl)-1-isopropyl-1H-benzoimidazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 870838-56-5
1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole

: 1226074-08-3
2-(4-fluorophenyl)-1-isopropyl-1H-benzimidazol-4-ylamine

: 1240608-38-1
[2-(4-fluorophenyl)-1-isopropyl-1H-benzoimidazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

Guidance literature:: With caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 100 ℃; Inert atmosphere;

Reference yield:

: 1240610-56-3
C₁₆H₁₄FN₃O₂

: 1240608-38-1
[2-(4-fluorophenyl)-1-isopropyl-1H-benzoimidazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1: iron / acetic acid / 1 h / 60 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

With palladium diacetate; iron; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In acetic acid; toluene;
DOI:10.1021/jm201710f

Reference yield:

: 1009-36-5
2-chloro-5-nitroanisole

: 1240608-38-1
[2-(4-fluorophenyl)-1-isopropyl-1H-benzoimidazol-4-yl]-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 6 h / 150 °C / Autoclave; Inert atmosphere

2.1: 10% Pd/C; hydrogen / methanol / 12 h / 50 °C / 760.05 Torr

3.1: sulfuric acid; sodium nitrite / acetic acid / 0.5 h / 10 - 20 °C

3.2: 1 h / 20 °C

4.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 100 °C / Inert atmosphere

With sulfuric acid; 10% Pd/C; hydrogen; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; sodium nitrite; In methanol; acetic acid; dimethyl sulfoxide; toluene;
DOI:10.1021/jm201710f