2-(7,8-dimethoxy-5,10-dihydropyrrolo[1,2-b]isoquinolin-10-yl)-N,N-diethylacetamide

Base Information

Chemical Name:2-(7,8-dimethoxy-5,10-dihydropyrrolo[1,2-b]isoquinolin-10-yl)-N,N-diethylacetamide
CAS No.:1133436-82-4
Molecular Formula:C₂₀H₂₆N₂O₃
Molecular Weight:342.438
Hs Code.:

Synonyms:2-(7,8-dimethoxy-5,10-dihydropyrrolo[1,2-b]isoquinolin-10-yl)-N,N-diethylacetamide

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Chemical Property of 2-(7,8-dimethoxy-5,10-dihydropyrrolo[1,2-b]isoquinolin-10-yl)-N,N-diethylacetamide

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Technology Process of 2-(7,8-dimethoxy-5,10-dihydropyrrolo[1,2-b]isoquinolin-10-yl)-N,N-diethylacetamide

There total 4 articles about 2-(7,8-dimethoxy-5,10-dihydropyrrolo[1,2-b]isoquinolin-10-yl)-N,N-diethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1213766-87-0
(E)-N',N'-diethyl-3-[N-(2-iodo-4,5-dimethoxybenzyl)-1H-pyrrol-2-yl]acrylamide

: 1133436-82-4
2-(7,8-dimethoxy-5,10-dihydropyrrolo[1,2-b]isoquinolin-10-yl)-N,N-diethylacetamide

: 1133436-87-9
3-[1-(3,4-dimethoxybenzyl)-1H-pyrrol-2-yl]-N,N-diethyl-4,4-dimethylpentanamide

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1002/ejoc.201200994

Reference yield:

: 293732-19-1
(4,5-dimethoxy-2-iodophenyl)methyl bromide

: 1133436-82-4
2-(7,8-dimethoxy-5,10-dihydropyrrolo[1,2-b]isoquinolin-10-yl)-N,N-diethylacetamide

: 1133436-87-9
3-[1-(3,4-dimethoxybenzyl)-1H-pyrrol-2-yl]-N,N-diethyl-4,4-dimethylpentanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 2 h / 20 °C

1.2: 4 h

2.1: dichloromethane / 96 h / Reflux

3.1: tert.-butyl lithium; N,N,N,N,-tetramethylethylenediamine / hexane; tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; potassium hydroxide; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; 2.1: |Wittig Olefination;
DOI:10.1002/ejoc.201200994

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 1133436-82-4
2-(7,8-dimethoxy-5,10-dihydropyrrolo[1,2-b]isoquinolin-10-yl)-N,N-diethylacetamide

: 1133436-87-9
3-[1-(3,4-dimethoxybenzyl)-1H-pyrrol-2-yl]-N,N-diethyl-4,4-dimethylpentanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 2 h / 20 °C

1.2: 4 h

2.1: dichloromethane / 96 h / Reflux

3.1: tert.-butyl lithium; N,N,N,N,-tetramethylethylenediamine / hexane; tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere

With N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; potassium hydroxide; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; 2.1: |Wittig Olefination;
DOI:10.1002/ejoc.201200994