293732-19-1

Upstream product

• 110451-87-1 2-bromomethyl-1-iodo-4,5-dimethoxybenzene 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 
• 58432-83-0 (4,5-dimethoxy-2-iodophenyl)methyl chloride 

Downstream Products

• 445006-98-4 3-(2-iodo-4,5-dimethoxyphenyl)-2,2-dimethylpropanenitrile 
• 495414-19-2 3-(2-iodo-4,5-dimethoxyphenyl)-2,2-diphenylpropanenitrile 
• 851384-83-3 [1-(2-iodo-4,5-dimethoxy-benzyl)-1H-pyrrol-2-yl]-morpholin-4-yl-methanone 
• 916977-11-2 1-iodo-2-iodomethyl-4,5-dimethoxybenzene 
• 1104967-37-4 3-(2-iodo-4,5-dimethoxybenzyl)-7,8-dimethoxy-1,3-dihydrobenzo[d]azepin-2-one 
• 1133436-77-7 1-(2-iodo-4,5-dimethoxybenzyl)-1H-pyrrole-2-carbaldehyde 
• 1133436-88-0 1-[1-(2-iodo-4,5-dimethoxybenzyl)-1H-pyrrol-2-yl]ethan-1-one 
• 1018331-31-1 C₁₉H₂₁IN₂O₃ 
• 1394134-48-5 N-(2-iodo-4,5-dimethoxybenzyl)-N-methylaniline 

Relevant academic research and scientific papers

Enantioselective Palladium-Catalyzed Heck-Heck Cascade Reactions: Ready Access to the Tetracyclic Core of Lycorane Alkaloids

A rapid and efficient access to a wide variety of enantiomerically enriched C-11b substituted lycorane analogues can be achieved via a catalytic asymmetric Heck-Heck 6-exo/6-endo cascade reaction in the presence of (R)-BINAP.

Benzannulated cyclooctanol derivatives by samarium diiodide induced intramolecular carbonyl-alkene coupling - Scope, limitations, stereoselectivity

A series of γ-oxo esters 27-34 was prepared from methyl 2-silyloxycyclopropanecarboxylates 1-9 as key building blocks in a flexible modular synthesis. Their samarium diiodide promoted cyclization to benzannulated cyclooctanol derivatives was systematicall

An efficient entry to pyrrolo[1,2-b]isoquinolines and related systems through Parham cyclisation

Aryllithiums generated by lithium-iodine exchange undergo intramolecular cyclisation to give pyrrolo[1,2-b]isoquinolines, in high yields. The best results were obtained when Weinreb or morpholine amides were used as internal electrophiles. The procedure h

NOVEL HETEROCYCLIC COMPOUNDS AS HSP90-INHIBITORS

Novel heterocyclic compounds are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agent. Method of synthesis and use of such compounds are also described.

Parham-type cycliacylation with Weinreb amides. Application to the synthesis of fused indolizinone systems

(Matrix presented) Weinreb amides behave as efficient internal electrophiles in Parham-type cycliacylation reactions. Thus, aryl- and heteroaryllithiums generated by lithium-halogen exchange undergo intramolecular cyclization to give fused indolizinone systems as pyrrolo[1,2-b]isoquinolines, thieno[2,3-f]indolizinones, and pyrrolo[1,2-b]acridinones in high yields.

Carbopalladation of nitriles: Synthesis of benzocyclic ketones and cyclopentenones via Pd-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles and related compounds

An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)-propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functional groups. This methodology has been extended to the synthesis of tetralones and cyclopentenones.

A Convenient Strategy for the Synthesis of 4,5-Bis(o-haloaryl)isoxazoles

A series of new 1,2-bis(o-haloaryl)ethanones is efficiently prepared and applied to the synthesis of 4,5-bis(o-haloaryl)isoxazoles. Isolation of intermediate hydroxyisoxazolines, which are structurally examined, provides a definitive proof for a heterocyclization mechanism based on an amine exchange process. The isolation and X-ray crystallographic studies of significant side products such as benzamides and triarylpropionitriles are also described.