Δ^1,7-dafachronic acid

Base Information

• Chemical Name: Δ^1,7-dafachronic acid
• CAS No.: 1377666-88-0
• Molecular Formula: C₂₇H₄₀O₃
• Molecular Weight: 412.613

Synonyms:Δ^1,7-dafachronic acid

Chemical Property of Δ^1,7-dafachronic acid

Chemical Property:

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Technology Process of Δ^1,7-dafachronic acid

There total 1 articles about Δ^1,7-dafachronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate (14773-00-3) → Δ1,7-dafachronic acid (1377666-88-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

1.2: 0 °C

2.1: 2-iodoxybenzoic acid; trifluoroacetic acid / dimethyl sulfoxide / 60 °C / Darkness

3.1: lithium; ammonia / tert-butyl alcohol; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 0.25 h / 20 °C

4.2: 20 °C

5.1: Burgess Reagent / toluene / Reflux

6.1: lithium hydroxide / methanol; tetrahydrofuran; water / 20 °C

7.1: methanol / 0.25 h / Inert atmosphere

7.2: 3.02 h / 50 °C

8.1: 2-iodoxybenzoic acid; trifluoroacetic acid / dimethyl sulfoxide / 70 °C

With Burgess Reagent; 2-iodoxybenzoic acid; ammonia; lithium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; toluene; acetonitrile; tert-butyl alcohol; 5.1: |Burgess Alcohol Dehydration;

DOI:10.1002/anie.201307465

upstream raw materials:

methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate

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