Technology Process of 2-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-ethylamine
There total 11 articles about 2-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-ethylamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine;
In
tert-butyl alcohol;
for 3h;
Heating;
DOI:10.1021/jo00317a027
- Guidance literature:
-
Multi-step reaction with 10 steps
1: potassium carbonate / acetone / 60 h
2: 15 h / Heating
3: sodium hydride / 1) 20 min at 0 deg C 2) reflux for 12 h
4: sodium hydroxide / 1) 1h reflux with NaOH 2) concentrated HCl
5: thionyl chloride
6: dimethylsulfide; ozone / 1) 3 in MeOH at -78 deg C 2) room temperature overnight
7: sodium tetrahydroborate / ethanol / 3 h
8: pyridine / 24 h
9: N,N-dimethyl-formamide / 13 h / 60 - 65 °C
10: hydrazine / tert-butyl alcohol / 3 h / Heating
With
sodium hydroxide; sodium tetrahydroborate; thionyl chloride; dimethylsulfide; sodium hydride; potassium carbonate; ozone; hydrazine;
In
pyridine; ethanol; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/jo00317a027
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 15 h / Heating
2: sodium hydride / 1) 20 min at 0 deg C 2) reflux for 12 h
3: sodium hydroxide / 1) 1h reflux with NaOH 2) concentrated HCl
4: thionyl chloride
5: dimethylsulfide; ozone / 1) 3 in MeOH at -78 deg C 2) room temperature overnight
6: sodium tetrahydroborate / ethanol / 3 h
7: pyridine / 24 h
8: N,N-dimethyl-formamide / 13 h / 60 - 65 °C
9: hydrazine / tert-butyl alcohol / 3 h / Heating
With
sodium hydroxide; sodium tetrahydroborate; thionyl chloride; dimethylsulfide; sodium hydride; ozone; hydrazine;
In
pyridine; ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo00317a027
![2-{2-[3-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-2-methoxy-phenyl]-ethyl}-isoindole-1,3-dione](/Databaselist/images/loading.webp)
