methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxy]}-2-oxo-1-pyrrolidinyl]benzoate

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Chemical Name:methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxy]}-2-oxo-1-pyrrolidinyl]benzoate
CAS No.:936114-07-7
Molecular Formula:C₁₉H₂₈N₂O₆Si
Molecular Weight:408.527
Hs Code.:

Synonyms:methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxy]}-2-oxo-1-pyrrolidinyl]benzoate

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Chemical Property of methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxy]}-2-oxo-1-pyrrolidinyl]benzoate

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Technology Process of methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxy]}-2-oxo-1-pyrrolidinyl]benzoate

There total 1 articles about methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxy]}-2-oxo-1-pyrrolidinyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 6942-36-5
methyl 2-bromo-5-nitrobenzoate

: 106191-02-0
(S)-5-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-2-one

: 936114-07-7
methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxy]}-2-oxo-1-pyrrolidinyl]benzoate

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane;
DOI:10.1016/j.tetlet.2007.02.008

Reference yield: 97.0%

: 936114-07-7
methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxy]}-2-oxo-1-pyrrolidinyl]benzoate

: 936114-23-7
methyl 5-amino-2-[(5S)-5-{[(tert-butyl)dimethylsilyiloxy]}-2-oxo-1-pyrrolidinyl]benzoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1016/j.tetlet.2007.02.008

Reference yield:

: 936114-07-7
methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxy]}-2-oxo-1-pyrrolidinyl]benzoate

: methyl 5-iodo-2-[(5S)-5-{hydroxymethy}-2-oxo-1-pyrrolidinyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / H₂ / Pd/C / ethanol

2: n-C₅H₁₁ONO; CH₂I₂

3: TBAF / tetrahydrofuran

With diiodomethane; n-Amyl nitrite; tetrabutyl ammonium fluoride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tetlet.2007.02.008