6942-36-5

Basic information

• Product Name: Methyl 2-bromo-5-nitrobenzoate
• Synonyms: METHYL 2-BROMO-5-NITROBENZOATE;METHYL 2-BROMO-5-NITROBENZOIC ACID;2-BROMO-5-NITROBENZOIC ACID METHYL ESTER;Methyl 2-bromo-5-nitrobenzoate, 98+%
• CAS NO: 6942-36-5
• Molecular Formula: C₈H₆BrNO₄
• Molecular Weight: 260.04
• EINECS: -0
• Product Categories: Aromatic Esters;Acids & Esters;Bromine Compounds;Nitro Compounds;C8 to C9;Carbonyl Compounds;Esters;Building Blocks;C8 to C9;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 6942-36-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 79-81 °C(lit.)
• Boiling Point: 326.7 °C at 760 mmHg
• Flash Point: 151.4 °C
• Appearance: Yellow/Crystalline Powder
• Density: 1.673 g/cm³
• Vapor Pressure: 0.000212mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, DCM. Ethyl Acetate
• BRN: 2617575
• CAS DataBase Reference: Methyl 2-bromo-5-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-bromo-5-nitrobenzoate(6942-36-5)
• EPA Substance Registry System: Methyl 2-bromo-5-nitrobenzoate(6942-36-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 6942-36-5(Hazardous Substances Data)

Usage

Chemical Properties

yellow crystalline powder

Uses

Methyl 2-bromo-5-nitrobenzoate may be used in chemical synthesis.

InChI:InChI=1/C8H6BrNO4/c1-14-8(11)6-4-5(10(12)13)2-3-7(6)9/h2-4H,1H3

Upstream product

• 18107-18-1 diazomethyl-trimethyl-silane 
• 943-14-6 2-bromo-5-nitrobenzoic acid 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 67-56-1 methanol 

Downstream Products

• 243122-77-2 Methyl 2-(4-(1-Adamantyl)phenyl)-5-nitrobenzoate 
• 373623-07-5 methyl 5-nitro-2-(2-methoxy-6-methoxymethoxyphenyl)-benzoate 
• 332883-48-4 (2-bromo-5-nitro-phenyl)methanol 
• 900503-41-5 3-(2-methoxycarbonyl-4-nitro-phenyl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 
• 6942-37-6 5-amino-2-bromo-benzoic acid methyl ester 
• 602295-92-1 2'-fluoro-4-nitro-biphenyl-2-carboxylic acid 
• 602296-62-8 6-(3-fluoro-2-hydroxy-phenyl)-5-hydroxymethyl-2,2,4-trimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester 
• 602296-12-8 6-(5-bromo-2,3-dimethoxy-phenyl)-5-hydroxymethyl-2,2,4-trimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester 
• 602296-76-4 6-(5-bromo-2-hydroxy-3-methoxy-phenyl)-5-hydroxymethyl-2,2,4-trimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester 
• 602296-73-1 6-(5-bromo-3-fluoro-2-hydroxy-phenyl)-5-hydroxymethyl-2,2,4-trimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester 
• 602296-09-3 6-(5-bromo-3-fluoro-2-methoxy-phenyl)-5-hydroxymethyl-2,2,4-trimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester 
• 639475-81-3 C₁₁H₈N₂O₅ 
• 36749-41-4 2-bromo-3,5-dinitro-benzoic acid methyl ester 
• 313532-64-8 5-Nitro-2-[2-(3,4,5-trimethoxyphenyl)-2,3-dihydro-1H-isoindol-5-ylamino]benzoic acid 

Relevant articles and documents

Synthesis and photophysical properties of isocoumarin-based D-π-A systems

We prepared a small library of polarity-sensitive fluorescent dyes characterized by an isocoumarin core properly functionalized with a conjugated push-pull system. The key step of the synthesis is based on a regio-selective silver(I)/p-TSA co-catalyzed cyclization of 2-alkynylbenzoates recently optimized in our laboratory. The photophysical properties of isocoumarin-based D-π-A systems have been investigated and a rationale was proposed based on their dipole moments and Hammett constants of the ED and EW groups involved.

Supramolecular control of selectivity in hydroformylation of vinyl arenes: Easy access to valuable β-aldehyde intermediates

Go against the flow! A rationally designed regioselective hydroformylation catalyst, [Rh/L], in which noncovalent ligand-substrate interactions allow the unprecedented reversal of selectivity from the typical α-aldehyde to the otherwise unfavored product β-aldehyde, is reported. This catalytic system opens up novel and sustainable synthetic pathways to important intermediates for the fine-chemicals industry.

Monna, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds. A structure-activity relationship revealed novel chemical classes of xANO1 blockers. The derivatives contain a-NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC 5050 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10～30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacological dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.