6942-36-5

Usage

Chemical Properties

yellow crystalline powder

Uses

Methyl 2-bromo-5-nitrobenzoate may be used in chemical synthesis.

InChI:InChI=1/C8H6BrNO4/c1-14-8(11)6-4-5(10(12)13)2-3-7(6)9/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 943-14-6 2-bromo-5-nitrobenzoic acid 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 93186-53-9 1,3-Dichlor-7-nitro-9-oxo-fluoren 
• 179898-09-0 methyl (5'-fluoro-2'-methoxy-4-nitro-2-biphenyl)carboxylate 
• 641-13-4 anthanthrone 
• 243122-77-2 Methyl 2-(4-(1-Adamantyl)phenyl)-5-nitrobenzoate 
• 602295-91-0 2'-fluoro-4-nitro-biphenyl-2-carboxylic acid methyl ester 
• 373623-07-5 methyl 5-nitro-2-(2-methoxy-6-methoxymethoxyphenyl)-benzoate 
• 332883-48-4 (2-bromo-5-nitro-phenyl)methanol 
• 900503-41-5 3-(2-methoxycarbonyl-4-nitro-phenyl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 
• 936114-07-7 methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxy]}-2-oxo-1-pyrrolidinyl]benzoate 
• 936114-10-2 methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxyethyl]}-2-oxo-1-pyrrolidinyl]benzoate 
• 6942-37-6 5-amino-2-bromo-benzoic acid methyl ester 
• 1806-25-3 2-fluoro-7-nitro-fluorene 

Relevant academic research and scientific papers

Synthesis and photophysical properties of isocoumarin-based D-π-A systems

We prepared a small library of polarity-sensitive fluorescent dyes characterized by an isocoumarin core properly functionalized with a conjugated push-pull system. The key step of the synthesis is based on a regio-selective silver(I)/p-TSA co-catalyzed cyclization of 2-alkynylbenzoates recently optimized in our laboratory. The photophysical properties of isocoumarin-based D-π-A systems have been investigated and a rationale was proposed based on their dipole moments and Hammett constants of the ED and EW groups involved.

4,4-DIFLUORO-PIPERIDINE-COMPOUNDS

The invention, in a first aspect relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R is a 6-membered aromatic ring, or a 5- or 6-membered heteroaromatic ring comprising 1 to 3 heteroatoms selected from S, O and N,

4,4-DIFLUORO-PIPERIDINE-COMPOUNDS

The invention, in a first aspect relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R is a 6-membered aromatic ring, or a 5- or 6-membered heteroaromatic ring comprising 1 to 3 heteroatoms selected from S, O and N,

Monna, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1

Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds. A structure-activity relationship revealed novel chemical classes of xANO1 blockers. The derivatives contain a-NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC 5050 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10～30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacological dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

Supramolecular control of selectivity in hydroformylation of vinyl arenes: Easy access to valuable β-aldehyde intermediates

Go against the flow! A rationally designed regioselective hydroformylation catalyst, [Rh/L], in which noncovalent ligand-substrate interactions allow the unprecedented reversal of selectivity from the typical α-aldehyde to the otherwise unfavored product β-aldehyde, is reported. This catalytic system opens up novel and sustainable synthetic pathways to important intermediates for the fine-chemicals industry.

Donor-acceptor biaryl lactones: PH induced molecular switches with intramolecular charge transfer modulation

The physical properties of biaryl-containing compounds are known to be highly dependent on molecular geometry. We report the syntheses and fundamental spectroscopic study of two donor-acceptor biaryl lactone (6H-benzo[c]chromen-6- one) pH-driven switches.

NOVEL ANTHRANILIC ACID DERIVATIVES AND CHLORIDE CHANNEL BLOCKING AGENT CONTAINING THE SAME

The present invention relates to novel anthranilic acid derivatives represented by Chemical Formula I, and a chloride channel blocking agent containing the anthranilic acid derivative or its pharmacologically acceptable salts as an active ingredient. In another aspect, the present invention relates to a method of accurately and efficiently detecting the intracellular chloride channel inhibition and method of screening a chloride channel blocking agent.

Water-soluble polyimides and methods of making and using same

The present invention provides, among other things, water-soluble polyimides, methods of making water-soluble polyimides, and methods of using water-soluble polyimides, e.g., in optics applications as well as other applications.

Regiospecific synthesis of substituted nitrofluorenes and aminofluorenes with the Negishi coupling reaction as key step

A short regiospecific route to 7-alkyl/CF3 substituted 2-nitrofluorenes and 2-aminofluorenes is described. The synthesis takes advantage of the palladium(0)-catalysed Negishi coupling of methyl 2-bromo-5-nitrobenzoate with aromatic zinc species