8-(2,6-difluorophenyl)-2-hydroxy-4-phenylpyrido[2,3-d]pyrimidin-7(8H)-one

Base Information

Chemical Name:8-(2,6-difluorophenyl)-2-hydroxy-4-phenylpyrido[2,3-d]pyrimidin-7(8H)-one
CAS No.:1115184-21-8
Molecular Formula:C₁₉H₁₁F₂N₃O₂
Molecular Weight:351.312
Hs Code.:

Synonyms:8-(2,6-difluorophenyl)-2-hydroxy-4-phenylpyrido[2,3-d]pyrimidin-7(8H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-(2,6-difluorophenyl)-2-hydroxy-4-phenylpyrido[2,3-d]pyrimidin-7(8H)-one

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Technology Process of 8-(2,6-difluorophenyl)-2-hydroxy-4-phenylpyrido[2,3-d]pyrimidin-7(8H)-one

There total 2 articles about 8-(2,6-difluorophenyl)-2-hydroxy-4-phenylpyrido[2,3-d]pyrimidin-7(8H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1115184-15-0
C₁₄H₈ClF₂N₃O₃S

: 98-80-6
phenylboronic acid

: 1115184-21-8
8-(2,6-difluorophenyl)-2-hydroxy-4-phenylpyrido[2,3-d]pyrimidin-7(8H)-one

: C₂₀H₁₃F₂N₃O₃S

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 150 ℃; for 0.25h; Microwave irradiation;
DOI:10.1016/j.tetlet.2008.11.014

Reference yield:

: 911370-07-5
4-chloro-2-methylsulfinyl-8-(2,6-difluoro-phenyl)-8H-pyrido[2,3-d]pyrimidin-7-one

: 98-80-6
phenylboronic acid

: 1115184-21-8
8-(2,6-difluorophenyl)-2-hydroxy-4-phenylpyrido[2,3-d]pyrimidin-7(8H)-one

: 1165940-92-0
C₂₀H₁₃F₂N₃O₂S

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 150 ℃; for 0.25h; Microwave irradiation;
DOI:10.1016/j.tetlet.2008.11.014