(Z)-4-(benzo[b]thiophen-3-ylmethylene)-2-phenyl-4H-oxazol-5-one

Base Information

• Chemical Name: (Z)-4-(benzo[b]thiophen-3-ylmethylene)-2-phenyl-4H-oxazol-5-one
• CAS No.: 35523-49-0
• Molecular Formula: C₁₈H₁₁NO₂S
• Molecular Weight: 305.357
• Mol file: 35523-49-0.mol

Synonyms:(Z)-4-(benzo[b]thiophen-3-ylmethylene)-2-phenyl-4H-oxazol-5-one

Chemical Property of (Z)-4-(benzo[b]thiophen-3-ylmethylene)-2-phenyl-4H-oxazol-5-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-4-(benzo[b]thiophen-3-ylmethylene)-2-phenyl-4H-oxazol-5-one

There total 3 articles about (Z)-4-(benzo[b]thiophen-3-ylmethylene)-2-phenyl-4H-oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + benzothiophene-3-carboxaldehyde (5381-20-4) → (Z)-4-(benzo[b]thiophen-3-ylmethylene)-2-phenyl-4H-oxazol-5-one (35523-49-0)

Guidance literature:

Hippuric Acid; With triethylamine sulfate; at 80 ℃; for 0.0833333h; Green chemistry;

benzothiophene-3-carboxaldehyde; at 100 ℃; for 0.4h; Reagent/catalyst; stereoselective reaction; Green chemistry;

DOI:10.1039/c5ra09290f

Reference yield:

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + benzothiophene-3-carboxaldehyde (5381-20-4) → 4-benzo[b]thiophen-3-ylmethylene-2-phenyl-4H-oxazol-5-one (35523-49-0)

Guidance literature:

With acetic anhydride;

DOI:10.1002/ardp.19713041108

Reference yield:

→ 4-benzo[b]thiophen-3-ylmethylene-2-phenyl-4H-oxazol-5-one (35523-49-0)

Guidance literature:

/BRN= 267334/;

DOI:10.1021/jo01152a009 DOI:10.1039/jr9490001374

upstream raw materials:

Hippuric Acid

benzothiophene-3-carboxaldehyde