1-(2-methoxyphenyl)-3-chloroisoquinoline

Base Information

• Chemical Name: 1-(2-methoxyphenyl)-3-chloroisoquinoline
• CAS No.: 190188-43-3
• Molecular Formula: C₁₆H₁₂ClNO
• Molecular Weight: 269.73
• Mol file: 190188-43-3.mol

Synonyms:1-(2-methoxyphenyl)-3-chloroisoquinoline

Chemical Property of 1-(2-methoxyphenyl)-3-chloroisoquinoline

Chemical Property:

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Technology Process of 1-(2-methoxyphenyl)-3-chloroisoquinoline

There total 1 articles about 1-(2-methoxyphenyl)-3-chloroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1,3-dichloroisoquinoline (7742-73-6) + 2-Methoxyphenylboronic acid (5720-06-9) → 1-(2-methoxyphenyl)-3-chloroisoquinoline (190188-43-3)

Guidance literature:

With cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; for 6h; Heating;

DOI:10.1039/a605827b

Reference yield: 81.0%

1-(2-methoxyphenyl)-3-chloroisoquinoline (190188-43-3) → 1,1'-Bis-(2-methoxy-phenyl)-[3,3']biisoquinolinyl

Guidance literature:

With triphenylphosphine; sodium iodide; nickel dichloride; zinc; In tetrahydrofuran; for 3h; Heating;

DOI:10.1039/a605827b

Reference yield: 58.0%

phenylmagnesium bromide (100-58-3) + 1-(2-methoxyphenyl)-3-chloroisoquinoline (190188-43-3) → 1-(2-methoxyphenyl)-3-phenylisoquinoline

Guidance literature:

[1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; potassium iodide; In tetrahydrofuran; 1.) 0 deg C, 30 min, 2.) r.t., 30 min;

DOI:10.1039/a605827b

upstream raw materials:

1,3-dichloroisoquinoline

2-Methoxyphenylboronic acid

Refernces