2-allyl-2-benzylmalonic acid dimethyl ester

Base Information

• Chemical Name: 2-allyl-2-benzylmalonic acid dimethyl ester
• CAS No.: 145429-73-8
• Molecular Formula: C₁₅H₁₈O₄
• Molecular Weight: 262.306
• Mol file: 145429-73-8.mol

Synonyms:2-allyl-2-benzylmalonic acid dimethyl ester

Chemical Property of 2-allyl-2-benzylmalonic acid dimethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-allyl-2-benzylmalonic acid dimethyl ester

There total 6 articles about 2-allyl-2-benzylmalonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

allyl methyl carbonate (35466-83-2) + diethyl 2-benzylmalonate (607-81-8) → 2-allyl-2-benzylmalonic acid dimethyl ester (145429-73-8)

Guidance literature:

With N-methylcyclohexylamine; pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride; at 90 ℃; for 1h;

DOI:10.1016/j.tetlet.2009.05.079

Reference yield: 75.0%

dimethyl allylmalonate (40637-56-7) + benzyl bromide (100-39-0) → 2-allyl-2-benzylmalonic acid dimethyl ester (145429-73-8)

Guidance literature:

dimethyl allylmalonate; With sodium hydride; In tetrahydrofuran; at 25 ℃;

benzyl bromide; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo0268759

Reference yield: 40.0%

2-Benzyl-2-((Z)-3-iodo-allyl)-malonic acid dimethyl ester (138536-58-0) → (Z)-5-Benzyl-hex-2-enedioic acid dimethyl ester (138536-72-8) + (E)-5-Benzyl-hex-2-enedioic acid dimethyl ester (138536-62-6) + 2-allyl-2-benzylmalonic acid dimethyl ester (145429-73-8)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; trimethylsilyltributyltin; In N,N-dimethyl-formamide; at 60 ℃; for 0.5h;

DOI:10.1016/0022-328X(94)87005-5

upstream raw materials:

2-Benzyl-2-((Z)-3-iodo-allyl)-malonic acid dimethyl ester

dimethyl allylmalonate

benzyl bromide

2-allyl-2-(2-iodobenzyl)malonic acid dimethyl ester

Downstream raw materials:

C₁₅H₁₈O

methyl 2-allyl-3-phenylpropionate