(E)-2-fluoro-3-(4-nitrophenyl)acrylonitrile

Base Information

Chemical Name:(E)-2-fluoro-3-(4-nitrophenyl)acrylonitrile
CAS No.:130537-11-0
Molecular Formula:C₉H₅FN₂O₂
Molecular Weight:192.149
Hs Code.:

Synonyms:(E)-2-fluoro-3-(4-nitrophenyl)acrylonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-fluoro-3-(4-nitrophenyl)acrylonitrile

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Technology Process of (E)-2-fluoro-3-(4-nitrophenyl)acrylonitrile

There total 4 articles about (E)-2-fluoro-3-(4-nitrophenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 503-20-8
fluoroacetonitrile

: 555-16-8
4-nitrobenzaldehdye

: 130537-11-0
(E)-2-fluoro-3-(4-nitrophenyl)acrylonitrile

: 130537-10-9
(Z)-2-fluoro-3-(4-nitrophenyl)acrylonitrile

Guidance literature:: With diethyl chlorophosphate; lithium hexamethyldisilazane; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) hexane, -78 deg C, 5 min 2) THF a) to r.t., 1h b) 30 min, reflux;
DOI:10.1016/S0022-1139(00)80371-1

Reference yield:

: 1072287-86-5
(1,3-benzothiazol-2-ylsulfonyl)fluoroacetonitrile

: 555-16-8
4-nitrobenzaldehdye

: 130537-11-0
(E)-2-fluoro-3-(4-nitrophenyl)acrylonitrile

: 130537-10-9
(Z)-2-fluoro-3-(4-nitrophenyl)acrylonitrile

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; optical yield given as %de;
DOI:10.1021/jo801235x

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 1742-99-0
1-(2,2-difluorovinyl)-4-nitrobenzene

: 130537-11-0
(E)-2-fluoro-3-(4-nitrophenyl)acrylonitrile

: 130537-10-9
(Z)-2-fluoro-3-(4-nitrophenyl)acrylonitrile

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 20 ℃; Overall yield = 84 %; Overall yield = 32 mg; diastereoselective reaction; Inert atmosphere;
DOI:10.1039/c9nj02370d