tert-butyl 4-(3-(4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-(4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxylate
CAS No.:1246188-54-4
Molecular Formula:C₁₈H₂₄F₃N₃O₄
Molecular Weight:403.401
Hs Code.:

Synonyms:tert-butyl 4-(3-(4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-(4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(3-(4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-(3-(4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 35037-73-1
1-isocyanato-4-trifluoromethoxy-benzene

: 1246188-54-4
tert-butyl 4-(3-(4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxylate

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm100691c

Reference yield:

: 150008-24-5
tert-butyl 4-(hydroxyimino)piperidine-1-carboxylate

: 1246188-54-4
tert-butyl 4-(3-(4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: Raney nickel / methanol / 4 h / 20 °C

2: dichloromethane / 12 h / 20 °C

With Raney nickel; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2010.12.042

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1246188-54-4
tert-butyl 4-(3-(4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; hydroxylamine hydrochloride / ethanol / 1 h / Reflux

2: Raney nickel / methanol / 4 h / 20 °C

3: dichloromethane / 12 h / 20 °C

With pyridine; hydroxylamine hydrochloride; In methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2010.12.042