TPPU

Base Information

Chemical Name:TPPU
CAS No.:1222780-33-7
Molecular Formula:C16H20F3N3O3
Molecular Weight:359.348
Hs Code.:
Mol file:1222780-33-7.mol

Synonyms:TPPU;1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea;N-[1-(1-Oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea;TPPU Exclusive

Suppliers and Price of TPPU

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TPPU
1g
$ 1200.00

Tocris
TPPU ≥98%(HPLC)
50
$ 566.00

Tocris
TPPU ≥98%(HPLC)
10
$ 154.00

Sigma-Aldrich
TPPU ≥98% (HPLC)
5mg
$ 103.00

Sigma-Aldrich
TPPU ≥98% (HPLC)
25mg
$ 404.00

DC Chemicals
TPPU >98%
1 g
$ 1700.00

DC Chemicals
TPPU >98%
100 mg
$ 400.00

Crysdot
TPPU 98%
25mg
$ 282.00

Crysdot
TPPU 98%
10mg
$ 116.00

Crysdot
TPPU 98%
5mg
$ 67.00

Total 13 raw suppliers

Chemical Property of TPPU

Chemical Property:

Melting Point:195-196 °C
Boiling Point:448.9±45.0 °C(Predicted)
PKA:13.11±0.20(Predicted)
PSA：70.67000
Density:1.31±0.1 g/cm3(Predicted)
LogP:3.50950
Storage Temp.:2-8°C
Solubility.:DMSO: soluble10mg/mL, clear (warmed)

Purity/Quality:

99%, ^*data from raw suppliers

TPPU ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:: SDS file from LookChem

Useful:

Uses Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively). The pharmacokinetics of TPPU are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.[Cayman Chemical] TPPU is an epoxide hydrolase inhibitor, which has potential in the reduction of inflammatory pain. TPPU has been used as a soluble epoxide hydrolase (SEH) inhibitor to characterize its pharmacokinetic (PK) and pharmacodynamic properties in rodents. It has also been used as a SEH inhibitor to study its effects on 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME) concentrations in nervous tissues.

Technology Process of TPPU

There total 2 articles about TPPU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1246188-54-4
tert-butyl 4-(3-(4-(trifluoromethoxy)phenyl)ureido)piperidine-1-carboxylate

: 79-03-8
propionyl chloride

: 1222780-33-7
N-[1-(1-Oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere; Cooling with ice;
DOI:10.1021/jm100691c

Reference yield:

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 35037-73-1
1-isocyanato-4-trifluoromethoxy-benzene

: 1222780-33-7
N-[1-(1-Oxopropyl)-4-piperidinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 12 h / 20 °C / Cooling with ice

2: triethylamine / dichloromethane / 5 h / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;