methyl (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionate

Base Information

• Chemical Name: methyl (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionate
• CAS No.: 485813-13-6
• Molecular Formula: C₂₃H₃₇N₃O₆
• Molecular Weight: 451.563
• Mol file: 485813-13-6.mol

Synonyms:methyl (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionate

Chemical Property of methyl (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionate

There total 1 articles about methyl (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + (R)-2-(benzyloxycarbonyl)amino-3-[[N-(tert-butoxycarbonyl)-N-methyl]amino]-1-ethylaminopropane → methyl (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionate (485813-13-6)

Guidance literature:

In methanol; at 20 ℃; for 16h;

DOI:10.1002/jhet.5570390417

Reference yield: 90.0%

methyl (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionate (485813-13-6) → (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid (485813-14-7)

Guidance literature:

With sodium hydroxide; In water; for 2h; Heating;

DOI:10.1002/jhet.5570390417

Reference yield:

methyl (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionate (485813-13-6) → (R)-3-benzyloxycarbonylamino-1-ethyl-5-methyl-6-oxo-1,5-octahydrodiazocine (485813-17-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / NaOH / H₂O / 2 h / Heating

2: 8.0 g / CH₂Cl₂ / 3 h / 20 °C

3: 99 percent / benzotriazol-1-yloxytris(dimehtylamino)phosphonium*PF₆^(1-); Et₃N / CH₂Cl₂ / 16 h / 20 °C

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; water;

DOI:10.1002/jhet.5570390417

upstream raw materials:

acrylic acid methyl ester

Downstream raw materials:

(R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid

(R)-3-benzyloxycarbonylamino-1-ethyl-5-methyl-1,5-octahydrodiazocine

(R)-3-benzyloxycarbonylamino-1-ethyl-5-methyl-6-oxo-1,5-octahydrodiazocine