(R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid

Base Information

Chemical Name:(R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid
CAS No.:485813-14-7
Molecular Formula:C₂₂H₃₅N₃O₆
Molecular Weight:437.536
Hs Code.:

Synonyms:(R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid

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Chemical Property of (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid

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Technology Process of (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid

There total 2 articles about (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 485813-13-6
methyl (R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionate

: 485813-14-7
(R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid

Guidance literature:: With sodium hydroxide; In water; for 2h; Heating;
DOI:10.1002/jhet.5570390417

Reference yield:

: (R)-2-(benzyloxycarbonyl)amino-3-[[N-(tert-butoxycarbonyl)-N-methyl]amino]-1-ethylaminopropane

: 485813-14-7
(R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / methanol / 16 h / 20 °C

2: 90 percent / NaOH / H₂O / 2 h / Heating

With sodium hydroxide; In methanol; water;
DOI:10.1002/jhet.5570390417

Reference yield:

: 485813-14-7
(R)-3-[N-[[2-benzyloxycarbonylamino-3-(N-tert-butoxycarbonyl-N-methyl)amino]propyl]-N-ethyl]aminopropionic acid

: 485813-18-1
(R)-3-benzyloxycarbonylamino-1-ethyl-5-methyl-1,5-octahydrodiazocine

Guidance literature:: Multi-step reaction with 3 steps

1: 8.0 g / CH₂Cl₂ / 3 h / 20 °C

2: 99 percent / benzotriazol-1-yloxytris(dimehtylamino)phosphonium*PF₆^(1-); Et₃N / CH₂Cl₂ / 16 h / 20 °C

3: 71 percent / LiAlH₄ / tetrahydrofuran / 3 h / 5 °C

With lithium aluminium tetrahydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/jhet.5570390417