ethyl (E)-2-(3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropanamido)acetate

Base Information

Chemical Name:ethyl (E)-2-(3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropanamido)acetate
CAS No.:604784-54-5
Molecular Formula:C₃₁H₃₁N₃O₆
Molecular Weight:541.604
Hs Code.:

Synonyms:ethyl (E)-2-(3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropanamido)acetate

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Chemical Property of ethyl (E)-2-(3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropanamido)acetate

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Technology Process of ethyl (E)-2-(3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropanamido)acetate

There total 5 articles about ethyl (E)-2-(3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropanamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 623-33-6
glycine ethyl ester hydrochloride

: 250601-51-5
(E)-3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropionic acid

: 604784-54-5
ethyl (E)-2-(3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropanamido)acetate

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1248/cpb.51.138

Reference yield:

: 250602-85-8
4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyamine

: 604784-54-5
ethyl (E)-2-(3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropanamido)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / acetic acid; sodium acetate / ethanol / 12 h / Heating

2: 99 percent / aq. lithium hydroxide / tetrahydrofuran / 18 h / 20 °C

3: 86 percent / WSC; HOBt; Et₃N / dimethylformamide / 18 h / 20 °C

With lithium hydroxide; sodium acetate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.51.138

Reference yield:

: 250601-50-4
ethyl (E)-3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropionate

: 604784-54-5
ethyl (E)-2-(3-{4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]benzyloxyimino}-3-phenylpropanamido)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / aq. lithium hydroxide / tetrahydrofuran / 18 h / 20 °C

2: 86 percent / WSC; HOBt; Et₃N / dimethylformamide / 18 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.51.138