2-[4-[2-[6-(methylamino)-2-pyridinyl]ethoxy]phenyl]cyclopropaneacetic acid

Base Information

• Chemical Name: 2-[4-[2-[6-(methylamino)-2-pyridinyl]ethoxy]phenyl]cyclopropaneacetic acid
• CAS No.: 381226-91-1
• Molecular Formula: C₁₉H₂₂N₂O₃
• Molecular Weight: 326.395
• Mol file: 381226-91-1.mol

Synonyms:2-[4-[2-[6-(methylamino)-2-pyridinyl]ethoxy]phenyl]cyclopropaneacetic acid

Chemical Property of 2-[4-[2-[6-(methylamino)-2-pyridinyl]ethoxy]phenyl]cyclopropaneacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-[4-[2-[6-(methylamino)-2-pyridinyl]ethoxy]phenyl]cyclopropaneacetic acid

There total 14 articles about 2-[4-[2-[6-(methylamino)-2-pyridinyl]ethoxy]phenyl]cyclopropaneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H26N2O3 → 2-[4-[2-[6-(methylamino)-2-pyridinyl]ethoxy]phenyl]cyclopropaneacetic acid (381226-91-1)

Guidance literature:

With lithium hydroxide; In acetonitrile; at 55 ℃; for 2h;

DOI:10.1016/j.bmc.2007.03.020

Reference yield:

ethyl 1-(p-methoxyphenyl)cyclopropane-2-acetate (853400-99-4) → 2-[4-[2-[6-(methylamino)-2-pyridinyl]ethoxy]phenyl]cyclopropaneacetic acid (381226-91-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / boron tribromide / CH₂Cl₂ / 18 h / 20 °C

2: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

3: aq. LiOH / acetonitrile / 2 h / 55 °C

With lithium hydroxide; di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetonitrile; 2: Mitsunobu reaction;

DOI:10.1016/j.bmc.2007.03.020

Reference yield:

(N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide (853401-03-3) → 2-[4-[2-[6-(methylamino)-2-pyridinyl]ethoxy]phenyl]cyclopropaneacetic acid (381226-91-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / sodium hydroxide / ethanol / 24 h / 20 °C

2: 82 percent / hydrochloric acid / 18 h / Heating

3: 89 percent / boron tribromide / CH₂Cl₂ / 18 h / 20 °C

4: triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

5: aq. LiOH / acetonitrile / 2 h / 55 °C

With hydrogenchloride; lithium hydroxide; sodium hydroxide; di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 4: Mitsunobu reaction;

DOI:10.1016/j.bmc.2007.03.020

upstream raw materials:

ethyl 1-(p-methoxyphenyl)cyclopropane-2-acetate

(N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide

1-(p-methoxyphenyl)cyclopropane-2-acetic acid

ethyl 1-(p-hydroxyphenyl)cyclopropane-2-acetate