(N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide

Base Information

• Chemical Name: (N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide
• CAS No.: 853401-03-3
• Molecular Formula: C₁₄H₁₉NO₃
• Molecular Weight: 249.31
• Mol file: 853401-03-3.mol

Synonyms:(N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide

Chemical Property of (N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide

There total 5 articles about (N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(N-methoxy-N-methyl)-4-(p-methoxyphenyl)but-3-enamide (689257-49-6) + Chloroiodomethane (593-71-5) → (N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide (853401-03-3)

Guidance literature:

With diethylzinc; In 1,2-dimethoxyethane; hexane; dichloromethane; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2007.03.020

Reference yield: 85.2%

(N-methoxy-N-methyl)-4-(p-methoxyphenyl)but-3-enamide (689257-49-6) + methyl iodide (74-88-4) → (N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide (853401-03-3)

Guidance literature:

methyl iodide; With diethylzinc; In hexanes; 1,2-dimethoxyethane; dichloromethane; at -15 ℃; for 0.333333h;

(N-methoxy-N-methyl)-4-(p-methoxyphenyl)but-3-enamide; In hexanes; dichloromethane; at -15 - 20 ℃; for 24h;

Reference yield:

(N-methoxy-N-methyl)-4-(p-methoxyphenyl)but-3-enamide (689257-49-6) + iodochloromethane(247 g,102 ML, 1.4 Mol) → (N-methoxy-N-methyl)-1-(p-methoxyphenyl)-2-cyclopropaneacetamide (853401-03-3)

Guidance literature:

In 1,2-dimethoxyethane; hexane; dichloromethane; ethyl acetate;

upstream raw materials:

(N-methoxy-N-methyl)-4-(p-methoxyphenyl)but-3-enamide

Chloroiodomethane

4-methoxy-benzaldehyde

(3E)-4-(4-methoxyphenyl)but-3-enoic acid

Downstream raw materials:

1-(p-methoxyphenyl)cyclopropane-2-acetic acid

ethyl 1-(p-methoxyphenyl)cyclopropane-2-acetate

ethyl 1-(p-hydroxyphenyl)cyclopropane-2-acetate

2-[4-[2-[6-(methylamino)-2-pyridinyl]ethoxy]phenyl]cyclopropaneacetic acid