3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)-2H-chromen-7-ol

Base Information

Chemical Name:3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)-2H-chromen-7-ol
CAS No.:1443752-75-7
Molecular Formula:C₂₉H₂₈F₃NO₄
Molecular Weight:511.541
Hs Code.:

Synonyms:3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)-2H-chromen-7-ol

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Chemical Property of 3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)-2H-chromen-7-ol

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Technology Process of 3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)-2H-chromen-7-ol

There total 12 articles about 3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)-2H-chromen-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.9%

: 3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)chroman-4,7-diol

: 1443752-75-7
3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)-2H-chromen-7-ol

Guidance literature:: With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

: 108-46-3
recorcinol

: 1443752-75-7
3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)-2H-chromen-7-ol

Guidance literature:: Multi-step reaction with 5 steps

1: boron trifluoride diethyl etherate / toluene / 1.5 h / 100 - 108 °C / Inert atmosphere

2: toluene-4-sulfonic acid / 0.75 h / -10 - 0 °C

3: piperidine / toluene / 24 h / Reflux

4: cesium fluoride / 48 h / 20 °C

5: trifluoroacetic anhydride; triethylamine / tetrahydrofuran / 16 h / 0 - 20 °C

With piperidine; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; cesium fluoride; trifluoroacetic anhydride; In tetrahydrofuran; toluene;

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 1443752-75-7
3-(4-hydroxyphenyl)-2-(4-(2-((R)-3-methylpyrrolidin-1-yl)ethoxy)phenyl)-4-(trifluoromethyl)-2H-chromen-7-ol

Guidance literature:: Multi-step reaction with 5 steps

1: boron trifluoride diethyl etherate / toluene / 1.5 h / 100 - 108 °C / Inert atmosphere

2: toluene-4-sulfonic acid / 0.75 h / -10 - 0 °C

3: piperidine / toluene / 24 h / Reflux

4: cesium fluoride / 48 h / 20 °C

5: trifluoroacetic anhydride; triethylamine / tetrahydrofuran / 16 h / 0 - 20 °C

With piperidine; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; triethylamine; cesium fluoride; trifluoroacetic anhydride; In tetrahydrofuran; toluene;