N-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}pentanamide

Base Information

• Chemical Name: N-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}pentanamide
• CAS No.: 667434-78-8
• Molecular Formula: C₂₀H₂₁N₃O₂
• Molecular Weight: 335.406
• Mol file: 667434-78-8.mol

Synonyms:N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)pentanamide

Chemical Property of N-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}pentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}pentanamide

There total 5 articles about N-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)aniline (775302-21-1) + n-valeryl chloride (638-29-9) → N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)pentanamide (667434-78-8)

Guidance literature:

With 3-Methylpyridine; In dichloromethane; at -5 - 5 ℃; for 4h;

DOI:10.1016/j.ejmech.2014.06.011

Reference yield:

methyl 3-nitrobenzoate (618-95-1) → N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)pentanamide (667434-78-8)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrazine hydrate / 6 h / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 3-Methylpyridine / dichloromethane / 12 h / 20 °C

3: trichlorophosphate / acetonitrile / 8 h / Reflux

4: hydrogen / methanol; tetrahydrofuran / 20 °C / 760.05 Torr

5: 3-Methylpyridine / dichloromethane / 4 h / -5 - 5 °C

With 3-Methylpyridine; hydrogen; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2014.06.011

Reference yield:

3-nitrobenzoic acid hydrazide (618-94-0) → N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)pentanamide (667434-78-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 3-Methylpyridine / dichloromethane / 12 h / 20 °C

2: trichlorophosphate / acetonitrile / 8 h / Reflux

3: hydrogen / methanol; tetrahydrofuran / 20 °C / 760.05 Torr

4: 3-Methylpyridine / dichloromethane / 4 h / -5 - 5 °C

With 3-Methylpyridine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.ejmech.2014.06.011

upstream raw materials:

methyl 3-nitrobenzoate

3-nitrobenzoic acid hydrazide

N'-(4-methylbenzoyl)-3-nitrobenzohydrazide

3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)aniline

Refernces