775302-21-1

Basic information

• Product Name: {3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}amine
• Synonyms: {3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}amine;3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]aniline;STK292579;ZINC06703635
• CAS NO: 775302-21-1
• Molecular Formula: C₁₅H₁₃N₃O
• Molecular Weight: 251.28322
• Mol File: 775302-21-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: {3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}amine(CAS DataBase Reference)
• NIST Chemistry Reference: {3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}amine(775302-21-1)
• EPA Substance Registry System: {3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}amine(775302-21-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 775302-21-1(Hazardous Substances Data)

Usage

General Description

{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}amine is a chemical compound with the molecular formula C15H13N3O. It is a derivative of 1,3,4-oxadiazole and belongs to the class of aromatic amines. {3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}amine has a phenylamine group as a substituent, which is attached to the 1,3,4-oxadiazol-2-yl ring. The 1,3,4-oxadiazole ring consists of a five-membered ring with two nitrogen atoms and one oxygen atom. This chemical is primarily used in medicinal and pharmaceutical research for the development of potential therapeutic agents due to the presence of the 1,3,4-oxadiazole moiety, which is known for its pharmacological activities. Additionally, it has applications in the field of organic synthesis and material science due to its unique structural features.

Upstream product

• 99-94-5 p-Toluic acid 
• 311313-24-3 N'-(4-methylbenzoyl)-3-nitrobenzohydrazide 
• 618-94-0 3-nitrobenzoic acid hydrazide 

Downstream Products

• 717828-35-8 2-(3,4-dimethoxyphenyl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 831215-29-3 2-(4-chlorophenyl)-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1418206-28-6 2-p-tolyl-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 1620517-24-9 methyl 4-oxo-4-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)butanoate 
• 1620516-93-9 4-hydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)butanamide 
• 1620517-25-0 methyl 5-oxo-5-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenylamino)pentanoate 
• 1620516-94-0 5-hydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)pentanamide 
• 1620516-96-2 7-hydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)heptanamide 
• 1620516-97-3 8-hydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)octanamide 
• 1620516-98-4 9-hydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)nonanamide 
• 1620516-99-5 10-hydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)decanamide 
• 1620517-00-1 5,6-dihydroxy-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)hexanamide 
• 1620517-33-0 C₁₉H₁₈IN₃O₂ 
• 1620517-08-9 4-morpholino-N-(3-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenyl)butanamide 

Relevant articles and documents

Synthesis and structure-activity relationship of non-phosphorus-based fructose-1,6-bisphosphatase inhibitors: 2,5-Diphenyl-1,3,4-oxadiazoles

With the aim of discovering a novel class of non-phosphorus-based fructose-1,6-bisphosphatase (FBPase) inhibitors, a series of 2,5-diphenyl-1,3,4-oxadiazoles were synthesized based on the hit compound (1) resulting from a high-throughput screening (HTS). Structure-activity relationship (SAR) studies led to the identification of several compounds with comparable inhibitory activities to AMP, the natural allosteric inhibitor of FBPase. Notably, compound 22 and 27b, bearing a terminal carboxyl or 1H-tetrazole, demonstrated remarkable inhibition to gluconeogenesis (GNG). In addition, both inhibition and binding mode to the enzyme were investigated by enzymatic kinetics and in silico experiments for representative compounds 16 and 22.