2-(2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-1-yl)ethanol

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Chemical Name:2-(2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-1-yl)ethanol
CAS No.:1428250-28-5
Molecular Formula:C₂₄H₂₇FN₈O
Molecular Weight:462.53
Hs Code.:

Synonyms:2-(2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-1-yl)ethanol

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Chemical Property of 2-(2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-1-yl)ethanol

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Technology Process of 2-(2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-1-yl)ethanol

There total 8 articles about 2-(2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-1-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428253-11-5
tert-butyl 4-(4-amino-6-(4-(4-(4-fluoro-3-methylphenyl)-1-(2-hydroxyethyl)-1H-imidazol-2-yl)piperidin-1-yl)pyrimidin-5-yl)-1H-pyrazole-1-carboxylate

: 1428250-28-5
2-(2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-1-yl)ethanol

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 3h;

Reference yield:

: 1226803-00-4
tert-butyl 4-(4-bromo-1-(2-hydroxyethyl)-1H-imidazol-2-yl)piperidine-1-carboxylate

: 1428250-28-5
2-(2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-1-yl)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 50 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

3: caesium carbonate / dimethyl sulfoxide / 100 °C

4: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 50 °C / Inert atmosphere

5: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

With hydrogenchloride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; methanol; water; dimethyl sulfoxide;

Reference yield:

: 158654-96-7
4-(1H-imidazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 1428250-28-5
2-(2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-yl)piperidin-4-yl)-4-(4-fluoro-3-methylphenyl)-1H-imidazol-1-yl)ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 0.25 h / -46 °C

2.1: potassium hydroxide / dimethyl sulfoxide / 1.5 h

2.2: 4 h

2.3: 0.33 h / 20 °C

3.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 50 °C / Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

5.1: caesium carbonate / dimethyl sulfoxide / 100 °C

6.1: bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate / 1,4-dioxane; water / 50 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane; methanol / 3 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;